Mus musculus musculus
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ABSTRACT:
PROVIDER: PRJNA1048149 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Multi-omics Reveals Different Signatures of Obesity-Prone and Obesity-Resistant Mice
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Project description:Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expression signature of adipose tissue in a body mass index (BMI)-matched obese cohort of patients that are either insulin sensitive or insulin resistant. We determined the global gene expression signatures of omental and subcutaneous adipose tissue samples obtained from insulin-sensitive obese and insulin-resistant obese patients undergoing gastric bypass surgery.
2009-04-24 | E-GEOD-15773 | biostudies-arrayexpress
Project description:Rodents respond to chronic high fat diet in at least two ways: some of them may readily gain body weight and become obese (termed obesity-prone), and others may not (termed obesity-resistant). An integrated approach of transcript and metabolic profiling of obesity-prone and obesity-resistant rats has been conducted, showing significantly different transcript and metabolic profiles in the two phenotypes. The major transcriptional differences involved hepatic fatty acid metabolism and ketogenesis in response to 16 weeks of high fat diet. At the same time, the different metabolic profiles (in liver tissue extracts, serum, and urine) between the two phenotypes could be ascribed to the corresponding pathways identified with multivariate statistical analysis, including fatty acid metabolism, Krebs cycle, and amino acid metabolism. The integration of results from both transcript and metabolic profiling revealed the different responses to dietary intervention of the two phenotypes and the physiological basis of susceptibility to metabolic disease in obesity-prone rats from a systematic view.
2008-05-20 | GSE11492 | GEO
Project description:Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expression signature of adipose tissue in a body mass index (BMI)-matched obese cohort of patients that are either insulin sensitive or insulin resistant. We determined the global gene expression signatures of omental and subcutaneous adipose tissue samples obtained from insulin-sensitive obese and insulin-resistant obese patients undergoing gastric bypass surgery. The SQ sample for Insulin Resistant Patient 6 has been removed from the study.
2010-04-07 | E-GEOD-20950 | biostudies-arrayexpress
Project description:Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the transgenerational effect of maternal obesity, we conducted a multi-omics study, using DNA methylation and gene expression in the CD34+/CD38-/Lin- umbilical cord blood hematopoietic stem cells (uHSCs) and metabolomics of the cord blood, all from a multi-ethnic cohort (n=72) from Kapiolani Medical Center for Women and Children in Honolulu, Hawaii (collected between 2016 and 2018). Differential methylation (DM) analysis unveiled a global hypermethylation pattern in the maternal pre-pregnancy obese group (BH adjusted p<0.05), adjusting for major clinical confounders. Functional analysis revealed significant associations of differentially methylated sites with downregulated cell cycle, lipid synthesis, immune signaling, and metabolic pathways. Utilizing Shannon entropy to evaluate uHSCs methylation levels, we discerned a notable impact of maternal obesity on higher quiescence of uHSCs. Further, the multi-omics integration revealed dysfunction in adipogenesis, erythropoietin production, cell differentiation and DNA repair. This study reveals a significant correlation between pre-pregnancy maternal obesity and multi-omics level molecular changes in the uHSCs of offspring, particularly in DNA methylation. These findings suggest that maternal obesity can lead to alterations that affect physiological pathways in the offspring.
2025-02-24 | GSE273074 | GEO
Project description:Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the transgenerational effect of maternal obesity, we conducted a multi-omics study, using DNA methylation and gene expression in the CD34+/CD38-/Lin- umbilical cord blood hematopoietic stem cells (uHSCs) and metabolomics of the cord blood, all from a multi-ethnic cohort (n=72) from Kapiolani Medical Center for Women and Children in Honolulu, Hawaii (collected between 2016 and 2018). Differential methylation (DM) analysis unveiled a global hypermethylation pattern in the maternal pre-pregnancy obese group (BH adjusted p<0.05), adjusting for major clinical confounders. Functional analysis revealed significant associations of differentially methylated sites with downregulated cell cycle, lipid synthesis, immune signaling, and metabolic pathways. Utilizing Shannon entropy to evaluate uHSCs methylation levels, we discerned a notable impact of maternal obesity on higher quiescence of uHSCs. Further, the multi-omics integration revealed dysfunction in adipogenesis, erythropoietin production, cell differentiation and DNA repair. This study reveals a significant correlation between pre-pregnancy maternal obesity and multi-omics level molecular changes in the uHSCs of offspring, particularly in DNA methylation. These findings suggest that maternal obesity can lead to alterations that affect physiological pathways in the offspring.
2025-02-24 | GSE272978 | GEO
Project description:The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles
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Project description:Effect of High Fat Diet on gene expression of liver from obesity-prone (C57BL/6J) and obesity-resistant (A/J) mice
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Project description:A multi-omics approach to decipher the complexity of drug resistance in diffuse large B-cell lymphoma
2025-01-23 | E-MTAB-6597 | ExpressionAtlas