Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNAseq data from 4 ASM-AHN, 3 CMML patients and 3 healthy donors

ABSTRACT: scRNAseq data from 4 ASM-AHN, 3 CMML patients and 3 healthy donors

PROVIDER: PRJNA1049047 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

scRNAseq data from 4 ASM-AHN, 3 CMML patients and 3 healthy donors

Project description:Aggressive systemic mastocytosis with associated hematologic neoplasm (ASM-AHN) represents a complex myeloid neoplasm, in which KIT D816V is the phenotype-defining but not the only driver mutation. Avapritinib is a potent and specific KIT D816V inhibitor recently approved for ASM treatment. To understand the effects of inhibiting KIT D816V on MC and Non-MC compartments, we combined single cell RNA sequencing (scRNAseq) with deep whole genome sequencing (WGS) to map clonal dynamics in successive blood samples from 4 ASM-AHN patients treated with avapritinib (T1 as pretreatment sample, T2 and T3 as posttreatment samples). Since CMML is the most common AHN associated with ASM, we included samples from three treatment-naïve KIT wild type CMML patients for comparison. We also included 3 age-matched healthy donor as controls.

2024-11-22 | GSE249445 | GEO

RNA-sequencing of Chronic Myelomonocytic Leukemia and healthy donors bone marrow samples

Project description:RNA-seq of bone marrow samples of chronic myelomonocytic leukemia (CMML) patients and healthy donors to identify the molecular DNA repair pathways involved in CMML pathogenic

2020-08-07 | GSE102312 | GEO

ScRNAseq analysis of data from patients with T1D and healthy donors

Project description:ScRNAseq analysis of data from patients with T1D and healthy donors

| PRJNA1364068 | ENA

Expression data from human bronchial airway smooth muscle (ASM) cells

Project description:Interleukin (IL)-17 plays an important and protective role in host defence and has been demonstrated to orchestrate airway inflammation by cooperating with and inducing proinflammatory cytokines. Mircoarrays were used to identify immediate-early/ primary response IL-17A-dependent gene transcripts in primary human bronchial ASM cells from mild asthmatic and healthy individuals. To evaluate IL-17A-inducible gene transcripts, primary human bronchial ASM cells from 3 mild asthmatic and 3 healthy donors were treated for 2h with IL-17 [10ng/ml] and were probed with the Affymetrix GeneChip array. The 2h time point was carefully chosen in order to identify primary response gene targets and to avoid confounding autocrine mechanisms mediating indirect, or late-phase gene expression responses. Non-stimulated ASM cells from the same patients were used as controls.

2012-02-09 | E-GEOD-35643 | biostudies-arrayexpress

Human blood monocytes scRNAseq

Project description:scRNAseq of human blood monocytes isolated with magnetic CD14+ beads from two healthy donors.

2022-10-05 | GSE211603 | GEO

ChiP-seq of H3K4me3 in primary unstimulated monocytes from 3 healthy donors buffy coats and from 4 CMML patients

Project description:ChiP-seq of H3K4me3 in primary unstimulated monocytes from 3 healthy donors buffy coats and from 4 CMML patients

| PRJEB26380 | ENA

ScRNAseq T1D

Project description:ScRNAseq analysis of data from patients with T1D and healthy donors

| PRJEB101445 | ENA

RNA-seq of human AML, CMML and MDS CD34+ blast cells, CD4+ T cells and CD8+ T cells treated with 5-aza against untreated samples and healthy controls

Project description:This study includes 2 cohorts of samples. First cohort consists out of BM aspirates from 4 healthy individuals and 12 patients diagnosed with AML, MDS or CMML. Second cohort includes 5 healthy individuals and 17 patients diagnosed with AML, MDS or CMML. MDS and CMML patients were treated with 5-AZA on 6 cycles and samples were obtained before the treatment and 15 days after 1 and 6 rounds of treatment.

2019-12-10 | E-MTAB-8208 | biostudies-arrayexpress

Gene expression profile at single-cell level of hematopoietic stem and progenitor cells (HSPCs) from individuals with chronic myelomonocytic leukemia (CMML)

Project description:Myeloblast expansion is a hallmark of disease progression in leukemias and comprises of CD34+ hematopoeitic stem and progeneitor cells. We used single-cell RNA sequencing (scRNAseq) to analyze the transcriptional states of HSPCs in CMML.

2022-11-04 | GSE211033 | GEO

Broncho brushing samples from healthy donors and Job's Syndrome patients

Project description:To find the DEGs between healthy donors and Job's Syndrome patients, we extracted RNA from broncho brushing samples collected from healthy donors and Job's Syndrome patients.

2025-12-02 | GSE288011 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data