Project description:The present study investigated whether maternal periodontal disease modifies the microRNA expression profile in adult offspring. *************************************************************** This study was supported by the São Paulo Research Foundation (FAPESP) [grant #2019/04183-9; #2022/08872-6; #2023/03786-7; #2023/12488-0; #2023/01400-4] and CNPq [grant 151151/2023-7], São Paulo, SP, Brazil. The grants #2019/04183-9; #2023/12488-0; #2023/01400-4 and 151151/2023-7 were awarded to the author Maria Sara de Lima Coutinho Mattera. The grant #2022/08872-6 was awarded to Heloisa Macedo Sampaio. The grant #2023/03786-7 was awarded to Gabriele Fernandes Baliero. ***************************************************************
Project description:This SuperSeries is composed of the SubSeries listed below to reproduce the data and analyses from Lareau et al. 2023 Nature Genetics
Project description:Comparison of copy number changes in MPNST samples against benign neurofibromas in NF1 patients 24 MPNSTs and 3 NF samples were hybridised to the human 32K BAC tiling path array
Project description:Individuals that recover from infections travel a path through disease space that returns to its origin. By following Plasmodium infected mice longitudinally from sickness to recovery, we show that these routes trace simple looping paths that can serve as maps. These maps can predict outcomes, reveal safe avenues and can help us avoid bad neighborhoods. Hosts that will suffer adverse effects enter regions of disease space that are not traversed by resilient individuals. Here we show that we can map disease outcomes using both longitudinal mouse data and cross-sectional human data. These maps identify relationships that could be useful in predicting and treating infections; they also show us that we commonly lack samples in regions of disease space that would help to build better predictive models.