Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer

ABSTRACT: N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer

PROVIDER: PRJNA1050279 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27151552_1.fastq.gz	Fastqsanger.gz
	SRR27151552_2.fastq.gz	Fastqsanger.gz
	SRR27151553_1.fastq.gz	Fastqsanger.gz
	SRR27151553_2.fastq.gz	Fastqsanger.gz
	SRR27151554_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

Project description:N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

| PRJNA1050281 | ENA

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

Project description:N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

| PRJNA1050277 | ENA

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

Project description:Our study examines the role of m6A RNA modification in regulating gene expression of transcripts promoting enzalutamide resistance in prostate cancer.

2024-05-01 | GSE249748 | GEO

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

Project description:Our study examines the role of m6A RNA modification in regulating gene expression of transcripts promoting enzalutamide resistance in prostate cancer.

2024-05-01 | GSE249749 | GEO

N6-methyladenosine modification is essential for prostate cancer cells

Project description:N6-methyladenosine modification is essential for prostate cancer cells

| PRJNA783056 | ENA

N6-methyladenosine modification is essential for prostate cancer cells

Project description:N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs) is a pivotal mechanism controlling mRNA fate in cells. RNA m6A modification is regulated by the functional balance between methyltransferases and demethylases. Here we demonstrated that FTO-IT1 enhancer RNA (eRNA), a long non-coding RNA (lncRNA) transcribed from the last intron of FTO gene is significantly upregulated in CRPC and aggressive tumors compared to primary tumors. FTO-IT1 knockout by CRISPR/Cas9 almost completely blocks growth and G1-S cell cycle transition of both androgen-sensitive and castration-resistant prostate cancer cells. Meanwhile, the mRNA m6A was dramatically increased in FTO-IT knockout PCa cells and we identified FTO-IT1 as a binding partner of FTO. From m6A-seq, we unexpectedly found hypermethylated m6A associated with upregulated levels of the mRNAs for p53 signaling pathway genes in 22Rv1 prostate cancer cells. Mechanistic study showed that FTO-IT1 recruits FTO to the P53 target mRNA to promote their m6A demethylation, which leads to their degradation.

2023-07-09 | GSE189465 | GEO

N6-Methyladenosine Modification Controls Circular RNA Immunity.

Project description:N6-Methyladenosine Modification Controls Circular RNA Immunity.

| PRJNA476784 | ENA

N6-methyladenosine RNA methylome analyses in human prostate cell lines.

Project description:To identify N6-methyladenosine RNA methylome in human prostate cell lines, MeRIP-seq of RWPE-1 and LNCaP were performed.

2021-08-11 | GSE147885 | GEO

Landscape of N6-methyladenosine modification patterns in human ameloblastoma

Project description:Landscape of N6-methyladenosine modification patterns in human ameloblastoma

| PRJNA659478 | ENA

Serrate modulates N6-Methyladenosine (m6A) RNA modification in Arabidopsis

Project description:Serrate modulates N6-Methyladenosine (m6A) RNA modification in Arabidopsis