Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mechanism underlying long-term visual dysfunction in the mouse model of oxygen-induced retinopathy

ABSTRACT: Mechanism underlying long-term visual dysfunction in the mouse model of oxygen-induced retinopathy

PROVIDER: PRJNA1051126 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27184824_1.fastq.gz	Fastqsanger.gz
	SRR27184824_2.fastq.gz	Fastqsanger.gz
	SRR27184825_1.fastq.gz	Fastqsanger.gz
	SRR27184825_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Mechanism underlying long-term visual dysfunction in the mouse model of oxygen-induced retinopathy

Project description:To investigate the mechanism of long-term visual dysfunction in the mouse model of oxygen-induced retinopathy (OIR) by performing RNA sequencing (RNA-seq) . Then further verify the results in transcriptional, expression and function, to explore the methods to improve its electrophysiological function and provide new ideas for the treatment of retinopathy of prematurity (ROP). 7 days C57BL/6 mice were placed in a closed hyperoxia chamber. After 5 days, they were raised in the ordinary air environment. On, the 17th day and 25th day, the eyes were removed. The results of RNA-seq in the retina of the OIR mice at P17 showed that compared with the normal control group, 102 differentially expressed genes were identified, of which 95 were significantly up-regulated and 7 were significantly down-regulated. This study provides a new idea of neuroprotection for the treatment of patients with mild premature retinopathy.

2024-12-31 | GSE249919 | GEO

Effects of inhibitors in mice with oxygen-induced retinopathy

Project description:Analysis of gene expression changes in oxygen-induced retinopathy mice treated intravitreally with inhibitors. oxygen-induced retinopathy(OIR)mice is one of the experimental systems that mimic retinal ischemic diseases. This model is widely used as an evaluation system for various surgical procedures.

2024-04-18 | GSE230668 | GEO

C57Bl6J retina lysates in oxygen-induced retinopathy

Project description:C57Bl6J retina lysates in oxygen-induced retinopathy

| PRJNA666571 | ENA

Effect of Caspase1 deletion on oxygen-induced retinopathy in C57BL/6 mice

Project description:To investigate the expression profile of genes involved in oxygen-induced retinopathy (OIR) and the effect of caspase1 deletion on those genes in retina.

2023-04-14 | GSE209654 | GEO

microRNA expression profile in retina and choroid in oxygen-induced retinopathy model

Project description:Using Next Generation Sequencing (NGS) we profiled miRNA expression in the retina and choroid during degenerative and NV phases of oxygen-induced retinopathy (OIR).

2019-04-18 | GSE129995 | GEO

Murine model of oxygen-induced retinopathy - 3 time points [retina]

Project description:To study early and late transcriptional changes introduced to blood and retinal tissue in murine oxygen-induced retinopathy (OIR). From retinal cells RNA was extracted at three time points: immediately after end of hyperoxia (P12), at P17 and P28.

2019-04-27 | GSE130400 | GEO

Murine model of oxygen-induced retinopathy - 3 time points [blood]

Project description:To study early and late transcriptional changes introduced to blood and retinal tissue in murine oxygen-induced retinopathy (OIR). From blood MNCs total RNA was extracted at three time points: immediately after end of hyperoxia (P12), at P17 and P28.

2019-04-26 | GSE130347 | GEO

Transcriptome analysis of the oxygen induced retinopathy (OIR) model at 5 different timepoints

Project description:High-throughput sequencing of murine retina of the oxygen induced retinopathy (OIR) model compared to control mice at 5 consecutive days (P12-P16)

2022-11-11 | GSE200195 | GEO

C57Bl6J retina lysates in oxygen-induced retinopathy

Project description:Schemic retinopathies such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP), are the main causes of blindness in working age and pediatric populations in industrialized countries. It is estimated that close to 100 million individuals worldwide suffer from DR and 15 million preterm infants born each year are predisposed to ROP. Regrettably, relatively little is known of the cellular processes at play during late stages of pathological angiogenesis in these diseases and consequently current standards of care target all neovascularization. Oxygen-induced retinopathy (OIR) allows to reproduce experimentally in the mouse retina the pathological features observed in human pathological retina such as ischemic avascular regions as well as epi-retinal neovascularization. Using agnostic and orthogonal approaches, in our work we demonstrate that in contrast to healthy blood vessels, pathological vessels engage pathways of cell cycle arrest, resulting in cellular senescence. These findings combined with further genetic and pharmacological approaches provide mechanistic evidence supporting that targeting selectively senescent vessels in DR represents a potential treatment for neovascular retinal disease.

2021-02-22 | GSE158799 | GEO

Expressing profiles of small non-coding RNA in mouse models of oxygen-induced retinopathy (OIR)

Project description:Pathologic ocular angiogenesis is a common cause of blindness in proliferative retinopathy. Small non-coding RNAs (sncRNAs) play critical roles in normal development and diseases, and their function in eye diseases and angiogenesis are increasingly recognized. In the present study, we aimed to identify the function and therapeutic potential of sncRNAs in retinopathy. We used microarray to analyze the retinal expression profile of sncRNAs in a mouse oxygen-induced retinopathy (OIR) model that mimic human proliferative retinopathy.

2017-02-10 | GSE84303 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data