Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fusobacterium polymorphum isolate:Inflamed gingiva

ABSTRACT: Fusobacterium polymorphum isolate:Inflamed gingiva Genome sequencing and assembly

PROVIDER: PRJNA1051802 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Fusobacterium polymorphum

Project description:Fusobacterium polymorphum overview

| PRJNA1205064 | ENA

RNA seqeuncing of Fusobacterium polymorphum strains from patients with leukoplakia

Project description:Fusobacterium polymorphum has been implicated in oral squamous cell carcinoma, yet its ubiquitous presence in healthy individuals complicates its role as a disease driver and raises the possibility that some clinical isolates may possess greater pathogenic potential than others. To explore potential functional differences among isolates, we performed transcriptomic profiling of F. polymorphum strains obtained from across the oral epithelial disease spectrum. Despite being genetically indistinguishable, isolates derived from dysplastic lesions exhibited distinct transcriptional signatures, including significant upregulation of genes involved in heme uptake compared with isolates from healthy sites. These findings suggest that transcriptional heterogeneity among clinical isolates may contribute to functional differences that could influence their pathogenic potential.

2026-03-11 | GSE324460 | GEO

Fusobacterium polymorphum strain:SSMR1 | isolate:29

Project description:Fusobacterium polymorphum strain:SSMR1 | isolate:29 Genome sequencing

| PRJNA855465 | ENA

Transcrptomic analysis of dysplastic oral keratinocytes infected with Fusobacterium polymorphum strains from patients with leukoplakia

Project description:Fusobacterium polymorphum has been implicated in oral squamous cell carcinoma, yet its widespread presence in the oral cavity raises questions about whether different clinical isolates exert distinct effects on host cells. To explore host transcriptional responses, we performed transcriptomic profiling of dysplastic oral keratinocytes (DOK) following exposure to F. polymorphum isolates derived from across the oral epithelial disease spectrum. The host transcriptomic response revealed a broadly shared pro-inflammatory signature across all isolates, regardless of their clinical origin. However, expression of genes and pathways associated with cell proliferation and related signaling processes varied among isolates and correlated with the dysplasia severity of the lesions from which the strains were derived. These findings suggest that while F. polymorphum isolates elicit a common inflammatory response in epithelial cells, variation in host transcriptional programs linked to proliferation may reflect differences in their biological impact.

2026-03-11 | GSE324461 | GEO

Fusobacterium polymorphum strain:3670

Project description:Fusobacterium polymorphum strain:3670 Genome sequencing

| PRJNA1246258 | ENA

Fusobacterium polymorphum ATCC 10953

Project description:Fusobacterium polymorphum ATCC 10953 Genome sequencing

| PRJNA178298 | ENA

Influence of dual-species coaggregation on transcriptional changes of Streptococcus gordonii and Fusobacterium nucleatum subsp. polymorphum

Project description:Interspecies coaggregation promotes transcriptional changes of oral bacteria, contributing to the development of structurally balanced biofilms as well as oral diseases such as periodontitis. Streptococcus gordonii (S. gordonii) is an early colonizer of the oral cavity, and Fusobacterium nucleatum (F. nucleatum) may act as a bridge adhering to both early and late oral colonizers. These two species were commonly detected in healthy and periodontitis-diseased oral sites and could interact with immune cells such as macrophages. However, little research explored how intergeneric coaggregation affected transcriptional changes in S. gordonii and F. nucleatum subsp. polymorphum and how these gene changes might affect both species’ pathogenicity. The present study investigated transcriptional changes of both species in response to dual-species physical association using dual RNA-seq. Results indicated that after 30-min dual-species coaggregation, 148 genes were significantly up-regulated, and 124 genes were significantly down-regulated in S. gordonii. A total of 154 genes were significantly down-regulated, and 10 genes were significantly up-regulated in F. nucleatum subsp. polymorphum. A majority of up-regulated S. gordonii genes were involved in the biosynthesis and export of cell-wall proteins and the pathway of carbohydrate metabolism, and a group of down-regulated S. gordonii genes were associated with fatty acid biosynthesis and peptidoglycan biosynthesis. The transcriptome profiles indicated that the interspecies coaggregation led to a reduced level of DNA repair and lipopolysaccharides virulence in F. nucleatum subsp. polymorphum. The present study revealed that dual-species coaggregation induced a wide array of gene changes in S. gordonii and F. nucleatum subsp. polymorphum, enhancing S. gordonii’s adherence ability and attenuating F. nucleatum subsp. polymorphum's ability to produce LPS.

2021-05-20 | GSE164282 | GEO

Fusobacterium polymorphum strain:ChDC F306

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1272

| PRJNA270146 | ENA

Fusobacterium polymorphum strain:KCOM 1265

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1265

| PRJNA657090 | ENA

Fusobacterium polymorphum strain:KCOM 1265

Project description:Fusobacterium polymorphum strain:KCOM 1265 Genome sequencing and assembly

| PRJNA416415 | ENA