Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

S ensory neurons shape local macrophage identity via TGF-β signaling

ABSTRACT: S ensory neurons shape local macrophage identity via TGF-β signaling

PROVIDER: PRJNA1054093 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vivo]

Project description:Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vivo]

| PRJNA1052759 | ENA

Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vitro]

Project description:Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vitro]

| PRJNA1054106 | ENA

Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vitro]

Project description:Macrophages play integral roles in maintaining homeostasis and function in their tissues of residence. In the skin, prenatally seeded and highly specialized macrophages physically interact with sensory nerves and contribute to their regeneration after injury. However, mechanisms underlying the development and maintenance of this paradigmatic, potentially lifelong commitment of macrophages to nociceptors remain largely elusive. Here, we found that infiltrating myeloid progenitor cells approached the sprouting axons of sensory nerves and gradually adopted a nerve-associated macrophage-like profile. This change in identity was steered and maintained by the immediate microenvironment, in particular TGF-β, which was produced by neurons and locally activated by the physical interaction with nerves and integrin-mediated cleavage. Following injury, TGF-β driven specification of macrophages essentially supported nerve regeneration. Overall, we identified TGF-β as a central mediator governing local imprinting and long-term specialization of macrophages in the skin, providing insights into the bidirectional communication between macrophages and sensory nerves.

2025-09-12 | GSE250456 | GEO

Sensory neurons imprint local macrophage identity via TGF-β [RNA-seq_in_vivo]

2025-09-12 | GSE250260 | GEO

Cytomegalovirus subverts macrophage identity

Project description:Cytomegalovirus subverts macrophage identity

| PRJNA668749 | ENA

S ensory neurons shape local macrophage identity via TGF-β signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-09-12 | GSE250457 | GEO

Cytomegalovirus subverts macrophage identity [LysMcreZeb1flox_vs_LysMcreZeb1wt]

Project description:Cytomegalovirus subverts macrophage identity [LysMcreZeb1flox_vs_LysMcreZeb1wt]

| PRJNA703928 | ENA