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Comparison of two materials effection on mice bone marrow mononuclear cells and cardiac repairing

ABSTRACT: Comparison of two materials effection on mice bone marrow mononuclear cells and cardiac repairing

PROVIDER: PRJNA1054560 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27292516_1.fastq.gz	Fastqsanger.gz
	SRR27292516_2.fastq.gz	Fastqsanger.gz
	SRR27292517_1.fastq.gz	Fastqsanger.gz
	SRR27292517_2.fastq.gz	Fastqsanger.gz
	SRR27292518_1.fastq.gz	Fastqsanger.gz

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Comparison of two materials effection on mice bone marrow mononuclear cells and cardiac repairing

Project description:Biomaterials can improve cardiac repair combined with transplantation of bone marrow mononuclear cells (BMMNCs). In this study, we compare the phenotype and cardiac repair between human heart valve-derived scaffold (hHVS) and nature protein/polycaprolactone (NP/PCL) anchored BMNNCs. Methods and Results: BMMNCs were obtained from mice five days following myocardial infarction. Subsequently, BMMNCs were separately cultured on hHVS and PCL. Proliferation and cardiomyogenic differentiation were detected in vitro. Cardiac function was measured after transplantation of cell-seeded cardiac patch on MI mice. After that, the BMMNCs were collected for mRNA sequencing after culturing on the scaffolds. Upon anchoring onto hHVS or PCL, BMMNCs exhibited an increased capacity for proliferation in vitro, however, the cells on hHVS exhibited superior ability cardiomyogenic differentiation ability. Moreover, both BMMNCs-seeded biomaterials effectively improved cardiac function after 4 weeks of transplantation, with reduced infarction area and restricted LV remodeling. Cell-seeded hHVS was superior to cell-seeded PCL. Conclusion: BMMNCs on hHVS show better capacity in both cell cardiac repairing and improvement for cardiac function than on PCL. Compared with seeded onto PCL, BMMNCs on hHVS have 253 genes up regulated and 189 genes down regulated. The reason of hHVS is better than PCL for a scaffold for BMMNCs might be the optimized method of decellularization let more cytokines in ECM retained.

2024-06-20 | GSE250573 | GEO

Bone marrow mononuclear cells

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Defining the molecular properties of the repairing epithelium during DSS induced colitis

Project description:In order to understand the molecular changes associated with the establishment of the repairing epithelium following dextran sulfate sodium (DSS) induced injury of the colon we have isolated Epcam+Sca1+ expressing epithelial cells from repairing tissue and Epcam+ homeostatic intestine. Cells isolated by flow cytometry were subjected to RNA extraction and analysed by expression analysis

2017-11-30 | E-MTAB-5249 | biostudies-arrayexpress

Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair.

Project description:Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) can improve the contractility of injured hearts.We hypothesized that mesodermal cardiovascular progenitors (hESC-CVPs), capable of generating vascular cells in addition to cardiomyocytes, would provide superior repair by contributing to multiple components of myocardium. We performed a head-to-head comparison of hESC-CMs and hESC-CVPs and compared these with the most commonly used clinical cell type, human bone marrow mononuclear cells (hBMMNCs). In a nude rat model of myocardial infarction, hESC-CMs and hESC-CVPs generated comparable grafts. Both similarly improved systolic function and ventricular dilation. Furthermore, only rare human vessels formed from hESC-CVPs. hBM-MNCs attenuated ventricular dilation and enhanced host vascularization without engrafting long-term or improving contractility. Thus, hESC-CMs and CVPs show similar efficacy for cardiac repair, and both are more efficient than hBM-MNCs. However, hESC-CVPs do not form larger grafts or more significant numbers of human vessels in the infarcted heart.

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Comparing two acetification profiles from natural raw materials: a quantitative approach in Komagataeibacter europaeus

Project description:The present work aims to compare two acetification profiles coming from the same starter culture but using different raw materials. For this purpose, the composition and natural behavior of the microbiota present throughout both processes were compared employing a metaproteomic analysis and, especially, focusing on the protein profile of K. europaeus from anexhaustive quantitative approach. A comparison of vinegar profiles using two natural raw materials (fine wine and craft beer) under a strategy that employs a submerged culture and a semi-continuous operating mode could improve the current knowledge about the influence of the raw materials on the organoleptic properties and quality of industrially elaborated vinegars.

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Comparative transcriptome analysis between two tomato materials under cold stress

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Comparative transcriptome analysis between two tomato materials under salt stress

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Butyrate-degrading enrichments with materials

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Silica materials effect on Bhas 42 cell transformation

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