Project description:In this study, we generated single-cell RNA sequencing (scRNA-seq) data from epithelial cells in the intestine, focusing on six distinct subsections during aging: the proximal small intestine, intermediate small intestine, distal small intestine, cecum, proximal colon and distal colon regions. Using a hashtag-labeled method, we aimed to create a comprehensive atlas of cellular changes during aging within these regions. Our objective is to uncover the underlying mechanisms of aging, leveraging the intestine as a model due to its highly proliferative nature. This dataset will provide valuable insights into the cellular dynamics of aging and contribute to the broader understanding of age-related processes.

2025-12-31 | GSE274687 | GEO

Immunoprofiling of prostate cancer infiltrate

Project description:Immunoprofiling of prostate cancer infiltrate

| PRJNA644438 | ENA

Immunoprofiling of Darier Disease patients

Project description:Immunoprofiling of Darier Disease patients

| PRJNA917428 | ENA

Immunoprofiling of mouse prostate cancer infiltrate

Project description:Immunoprofiling of mouse prostate cancer infiltrate

| PRJNA958227 | ENA

Immunoprofiling of Darier Disease patients

Project description:Darier disease (DD) is a rare, inherited multi-organ disorder associated with mutations in the ATP2A2 gene. In DD patients, the skin is frequently affected, characterized by malodorous, inflamed skin and recurrent, severe infections. Therapeutic options are limited and inadequate for the long-term management of this chronic disease. Using immunoprofiling with NanoString technology we demonstrate enhanced expression of Th-17-related genes and cytokines in five DD patients. We prove that targeting the IL-23/-17 axis in DD with monoclonal antibodies is an effective and safe therapy in DD patients, leading also to significant clinical improvement.

2023-09-23 | GSE222043 | GEO

miR-Blood - a small RNA sequencing atlas of purified human blood components

Project description:miR-Blood - a small RNA sequencing atlas of purified human blood components

| PRJNA937741 | ENA

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

Project description:Covid Immunoprofiling

| PRJEB57300 | ENA