Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

ABSTRACT: Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

PROVIDER: PRJNA1054687 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27292063_1.fastq.gz	Fastqsanger.gz
	SRR27292063_2.fastq.gz	Fastqsanger.gz
	SRR27292064_1.fastq.gz	Fastqsanger.gz
	SRR27292064_2.fastq.gz	Fastqsanger.gz
	SRR27292065_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Project description:Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. The inaccessible nature of the disease site and lack of understanding of the biology of this unique metastatic site are major barriers to developing efficacious therapies for patients with melanoma LMD. This study aims to characterize the tumor microenvironment of the leptomeningeal tissues and patient-matched extra-cranial metastatic sites using spatial transcriptomic analyses.

2024-06-03 | GSE250636 | GEO

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Project description: Not available

| S-EPMC10769278 | biostudies-literature

Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Project description: Not available

| S-EPMC11228800 | biostudies-literature

Individualised Treatment Approach for Advanced Meningeal Metastases: A Case Study of Ommaya Capsule Implantation

Project description:Leptomeningeal metastasis is a rare type of brain metastasis without effective therapeutic guidelines. Herein, we report emergency Ommaya capsule implantation performed for treating meningeal metastases from parathyroid carcinoma in a patient with intracranial hypertension. A 52-year-old woman was admitted to our hospital with recurrent headaches for 2 months and episodic vertigo for 2 days. The patient was hospitalised but did not exhibit abnormal intracranial signals. As her symptoms did not improve following transfer, the patient was diagnosed with a meningeal tumour, with a high suspicion of metastasis from parathyroid cancer. Conservative treatment was ineffective, and her symptoms worsened with severe headaches and shortness of breath.

2026-04-15 | GSE327068 | GEO

Transcriptome of mouse leptomeningeal fibroblats

Project description:Meninges, or the membranous coverings of the brain and spinal cord, play host to dozens of morbid pathologies. In this study we provide a method to isolate the leptomeningeal cell layer, identify leptomeninges in histologic slides, and maintain leptomeningeal fibroblasts in in vitro culture. Using an array of transcriptomic, histological, and cytometric analyses, we identified ICAM1 and SLC38A2 as two novel markers of leptomeningeal cells in vivo and in vitro. Our results confirm the fibroblastoid nature of leptomeningeal cells and their ability to form a sheet-like layer that covers the brain and spine parenchyma. These findings will enable researchers in central nervous system barriers to describe leptomeningeal cell functions in health and disease.

2021-09-29 | GSE150419 | GEO

Meningeal cells contribute to postnatal cortical neurogenesis.

Project description:Postnatal brain neurogenesis in mammals is believed to be restricted to rare germinative remnants of the neuroepithelium. In this study, we discovered that, in the postnatal brain, a subset of embryonically derived progenitors is present in meningeal substructures. These cells migrate from the meningeal substructures to the retrosplenial and visual motor cortex and differentiate into (electrically) functional integrated neurons. Lineage tracing analysis revealed that this subset of neural progenitors originate largely from PDGFR+ cells. PDGFR-derived cells differentiate mostly into Satb2+ neurons in cortical layers I-IV. Thus, a reservoir of embryonically derived progenitors in the meninges contributes to postnatal cerebral cortical neurogenesis.

2016-11-23 | E-MTAB-4951 | biostudies-arrayexpress

RNA Sequencing of sorted CD31+ meningeal endothelial cells from naïve Lewis rats

Project description:The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate in CNS autoimmunity but their relative contributions remain unclear. Here, we report on findings in animal models of CNS autoimmunity and in multiple sclerosis patients, where, in chronic disease, the leptomeninges were highly inflamed and showed structural changes, while the dura mater was only marginally affected. Although dural vessels were leakier than leptomeningeal vessels, effector T cells adhered more weakly to the dural endothelium. Furthermore, local antigen presenting cells presented myelin and neuronal autoantigens less efficiently and the activation of autoreactive T cells was lower in dural than leptomeningeal layers, preventing local inflammatory processes. Direct antigen application was required to evoke a local inflammatory response in the dura. Together, our data demonstrate an uneven involvement of the meningeal layers in CNS autoimmunity, in which effector T cell trafficking and activation are functionally confined to the leptomeninges, while the dura remains largely shielded from CNS autoimmune processes.

2022-07-04 | GSE203046 | GEO

Cellular and molecular signatures of the vascular microenvironment define the pre-metastatic brain and meninges [MERFISH]

Project description:The contribution of resident brain and meningeal cells in facilitating brain metastasis remains underappreciated. Here, we characterise the pre-metastatic molecular changes that occur in brain and meningeal resident cells in mouse models of breast cancer using single-cell and spatial transcriptomics. Increased inflammatory alterations preceding metastasis were identified in bridging veins spanning the leptomeninges, forming adhesion hotspots by upregulating Icam1 and Vcam1. Furthermore, bridging veins and encapsulating leptomeningeal fibroblasts upregulate cell trafficking ligands, including chemokines. Brain metastasising tumour cells correspondingly upregulate adhesion counter-receptor LFA-1 and chemokine receptors, demonstrating an enhanced capacity to traffic towards altered brain vessels and stroma. Moreover, PD-L1+ immunosuppressive neutrophils infiltrate the dura and brain, coupled with upregulation of checkpoint molecule PD-1 in CD8+ T cells. Neutrophils furthermore upregulate VEGFA, driving angiogenesis and vascular remodelling. These results indicate that breast cancers can drive multiple alterations in the leptomeningeal and dural vasculature that collectively facilitate formation of brain metastases.

2026-05-01 | GSE307719 | GEO

Cellular and molecular signatures of the vascular microenvironment define the pre-metastatic brain and meninges

2026-05-01 | GSE307433 | GEO

Cerebrospinal fluid microRNA profile in leptomeningeal metastasis patients [LM vs non-LM]

Project description:This study aimed to identify specific CSF miRNAs for diagnosing and monitoring leptomeningeal metastasis with lung adenocarcinoma. In discovery phase, we performed miRNA microarray analysis in CSF samples from leptomeningeal metastasis patients and non-leptomeningeal metastasis controls.

2020-02-26 | GSE125191 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data