Project description:Chronic hepatitis B (CHB) is a huge health burden in China, tongue diagnosis is the premise of personalized treatment of CHB by traditional Chinese medicine(TCM). The modern biological interpretation of pathological TCM tongue coating manifestation is unclear We performed transcriptional analysis in CHB patients with white tongue coating(WTC) or yellow tongue coating(YTC) to explain the potential inner biological differences
Project description:<p>Parkinson's disease (PD) is a prevalent neurodegenerative disorder with complex pathogenesis and limited treatment options. The current reliance on clinical evaluation for diagnosis, due to the absence of reliable non-invasive methods, presents significant challenges. Traditional diagnostic approaches, including cerebrospinal fluid (CSF) or blood sampling, are invasive, pose risks of infection, are costly, and often require complex procedures. Tongue coating sampling offers a non-invasive, cost-effective and repeatable alternative, showing promise for early detection and monitoring of PD. This study explores the feasibility of using tongue coating samples as a diagnostic tool for PD through microbiome analysis, with metabolomics data providing additional context and validation via machine learning models.</p>
