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Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells

ABSTRACT: Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells

PROVIDER: PRJNA1058485 | ENA |

REPOSITORIES: ENA

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Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Multiome]

Project description:Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Multiome]

| PRJNA1058464 | ENA

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Multiome]

Project description:Plasmacytoid dendritic cells (pDCs) mount powerful type I interferon (IFN-I) responses against viruses and virus-derived nucleic acids. Only a small fraction of pDCs produces high levels of IFN-I, yet neither the molecular basis nor the purpose of this functional heterogeneity are known. We report that naive murine pDCs comprise three transcriptionally (but not epigenetically) distinct subsets. This heterogeneity is generated by tonic IFN-I signaling elicited in part by the cGAS/STING and TLR9 pathways. A small "IFN-I-naive" subset (pDC-A) was expanded in STING deficiency or after transient IFN-I receptor blockade, but was abolished by exogenous IFN-I. pDC-A showed strong cytokine responses yet were susceptible to infection with vesicular stomatitis virus (VSV). Conversely, the majority of pDCs comprised the "IFN-I-primed" subsets (pDC-B/C) that showed lower IFN-I responses but were resistant to VSV. Thus, tonic IFN-I signaling decreases the cytokine-producing capacity of pDCs but increases their virus resistance, achieving the optimal functional balance for antiviral responses.

2025-08-05 | GSE252189 | GEO

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [CITE-seq]

Project description:Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [CITE-seq]

| PRJNA1058488 | ENA

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [CITE-seq]

2025-08-05 | GSE252190 | GEO

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Bulk RNA-seq]

Project description:Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Bulk RNA-seq]

| PRJNA1058465 | ENA

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells [Bulk RNA-seq]

2025-08-05 | GSE252188 | GEO

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-08-05 | GSE252191 | GEO

Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

Project description:Background Impaired interferon response and allergic sensitisation may contribute to virus induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDC) play a key role in antiviral immunity as critical producers of type I interferons (IFN-I). pDC also express the high affinity IgE receptor (FcRI) through which IFN-I production may be negatively regulated. If antiviral function of pDC is associated with recurrent episodes of wheeze in young children is not well understood. This study aimed to evaluate the phenotype and function of circulating pDC in children with a longitudinally defined wheezing phenotype. Methods We performed multiparameter flow cytometry on peripheral blood mononuclear cells from 38 children presenting to the emergency department with an acute episode of respiratory wheeze and 19 controls. RNA sequencing on isolated pDC from the same individuals was also performed. For each subject, their longitudinal exacerbation phenotype was determined using the Western Australia public hospital database. Results We observed a significant depletion of circulating pDC in young children with a persistent phenotype of wheeze. The same individuals also displayed upregulation of the IgE receptor (FcRI) on their pDC. Based on transcriptomic analysis, pDC from these individuals did not mount a robust systemic antiviral response as observed in children who displayed a non-recurrent wheezing phenotype. Conclusion Our data suggests that circulating pDC phenotype and function are altered in young children with a persistent longitudinal exacerbation phenotype. Expression of FcRI is increased and their function as major IFN producers is impaired during acute exacerbations of wheeze.

2023-12-17 | GSE243052 | GEO

Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells

Project description:Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells

| PRJNA687242 | ENA

RNA-seq of plasmacytoid dendritic cells stimulated by TLR3, TLR4, TLR7 and TLR8

Project description:Plasmacytoid dendritic cells (pDCs) are a rare type of dendritic cells that exist antiviral functions in response to toll-like receptors (TLRs). We here report TLR4 activated pDCs similar to TLR7/8 stimulation. Despite the high resemblance, we found the unique genes that were activated by TLR4 activation.

2023-07-31 | GSE236923 | GEO

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