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Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice

ABSTRACT: Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice

PROVIDER: PRJNA1059639 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27393300_1.fastq.gz	Fastqsanger.gz
	SRR27393300_2.fastq.gz	Fastqsanger.gz
	SRR27393301_1.fastq.gz	Fastqsanger.gz
	SRR27393301_2.fastq.gz	Fastqsanger.gz
	SRR27393302_1.fastq.gz	Fastqsanger.gz

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Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice

Project description:To investigate the molecular mechanism underlying zinc transporter in the endometrium during embryo implantation, we generated mice with uterine-specific deletion of one of zinc transporter, Zip10. We report the sequencing of the uterine transcriptome of control and uterine-specific Zip10-deficient mice at day 4 (1600h) of pregnancy.

2025-02-10 | GSE252322 | GEO

The zinc transporter ZIP10 regulates epidermal morphogenesis

Project description:We performed an mRNA-sequencing experiment using ZIP10 positive and negative cells isolated from the ventral skins of WT mice and analyzed gene expression profiles of those cells to identify the functional differences between the two cell types.

2017-10-05 | GSE83099 | GEO

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The GORKY Glycoalkaloid Transporter is Indispensable for Preventing Tomato Bitterness

Project description:Fruit taste is determined by sugars, acids and in some species, bitter chemicals. Attraction of seed-dispersing organisms in nature and breeding for consumer preferences requires reduced fruit bitterness. A key metabolic shift during ripening prevents tomato fruit bitterness by eliminating α-tomatine, a renowned defence-associated Solanum alkaloid. Here, we combined fine mapping with information from 150 re-sequenced genomes and genotyping a 650 tomato core collection to identify nine bitter-tasting accessions including the ‘high α-tomatine’ Peruvian landraces reported by Rick and colleagues (1994). These ‘bitter’ accessions contain a deletion in GORKY, a nitrate/peptide family (NPF) transporter mediating α-tomatine subcellular localization during fruit ripening. GORKY exports α-tomatine and its derivatives from the vacuole to the cytosol and this facilitates the conversion of the entire α-tomatine pool to non-bitter forms, rendering the fruit palatable. Hence, GORKY activity was a significant innovation in the process of tomato fruit domestication and breeding. The experiment was carried out to further prove that GORKY is localized to tonoplast in ripe fruit.

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Drought responsiveness dynamics in wheat

Project description:Drought responsiveness dynamics in wheat

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Sel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival

Project description:Sel1L is an adaptor protein for the E3 ligase Hrd1 involved in endoplasmic reticulum-associated degradation (ERAD). Its physiological importance in mammalian ERAD, however, remains to be established. Here, using the inducible Sel1L knockout mouse and cell models, we provide the first in vivo evidence that Sel1L is indispensable for Hrd1 stability, ER homeostasis and survival. Acute loss of Sel1L leads to premature death in adult mice within 3 weeks with profound pancreatic atrophy. Contrary to current belief, our data show that mammalian Sel1L is required for Hrd1 stability and ERAD function both in vitro and in vivo. Sel1L deficiency disturbs ER homeostasis, activates ER stress, attenuates translation and promotes cell death. Serendipitously, using biochemical approach coupled with mass spectrometry, we found that Sel1L deficiency causes the aggregation of both small and large ribosomal subunits. Thus, Sel1L is an indispensable component of mammalian ERAD and ER homeostasis, which is essential for protein translation, pancreatic function, cellular and organismal survival. Pancreas tissue of wild type and inducible Sel1L knockout mice were subjected to gene expression analysis.

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Successful Clinical Response in Pneumonia Therapy (SCRIPT)

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Transplantation-induced reprogramming determines successful hepatocyte engraftment

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Successful Clinical Response in Pneumonia Therapy (SCRIPT)

Project description:Successful Clinical Response in Pneumonia Therapy (SCRIPT)

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Gene expression analysis of RNAs isolated from WT and ZIP10-depleted human keratinocytes

Project description:To reveal the mechanisms by which ZIP10 contributes to keratinocyte differentiation, we used mRNAs isolated from human wild-type (WT) and ZIP10-knockdown (KD) keratinocytes in gene expression microarray analyses

2017-10-05 | GSE83098 | GEO

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