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Single T-cell receptor profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

ABSTRACT: Single T-cell receptor profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

PROVIDER: PRJNA1060684 | ENA |

REPOSITORIES: ENA

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Multimodal single-cell profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

Project description:Multimodal single-cell profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

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Multimodal single-cell profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

Project description:The redirection of T-cells has emerged as an attractive therapeutic principle in B-cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T-cells across B-NHL entities is missing. Here, we present cellular indexing of transcriptomes and epitopes of lymph-node derived T-cells from patients with diffuse large B-cell, mantle cell, follicular, or marginal zone lymphoma, and from healthy controls. These data revealed quantitative aberrations of the T-cell microenvironment across and within B-NHL entities.

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Single T-cell receptor profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

Project description:The redirection of T-cells has emerged as an attractive therapeutic principle in B-cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T-cells across B-NHL entities is missing. Here, we present single-cell transcriptome and T-cell receptor sequencing of lymph-node derived T-cells from patients with diffuse large B-cell, mantle cell, follicular, or marginal zone lymphoma, and from healthy controls. These data revealed quantitative aberrations of the T-cell microenvironment across and within B-NHL entities.

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Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities.

Project description:The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities is missing. Here we present an in-depth T cell reference map of nodal B-NHL, based on cellular indexing of transcriptomes and epitopes, T cell receptor sequencing, flow cytometry and multiplexed immunofluorescence applied to 101 lymph nodes from patients with diffuse large B cell, mantle cell, follicular or marginal zone lymphoma, and from healthy controls. This multimodal resource revealed quantitative and spatial aberrations of the T cell microenvironment across and within B-NHL entities. Quantitative differences in PD1+ TCF7- cytotoxic T cells, T follicular helper cells or IKZF3+ regulatory T cells were linked to their clonal expansion. The abundance of PD1+ TCF7- cytotoxic T cells was associated with poor survival. Our study portrays lymphoma-infiltrating T cells with unprecedented comprehensiveness and provides a unique resource for the investigation of lymphoma biology and prognosis.

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Epigenome analysis of nodal marginal zone lymphoma and diffuse large b cell lymphoma

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Molecular characterization of Nodal marginal zone lymphoma

Project description:This SuperSeries is composed of the following subset Series: GSE32231: Molecular characterization of Nodal marginal zone lymphoma [Gene Expression] GSE32232: microRNA-expression profile in a series of Nodal marginal zone lymphoma patients [miRNA expression] Refer to individual Series

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Nodal

Project description:Mus musculus Nodal, nodal [Source:MGI Symbol;Acc:MGI:97359], is differentially expressed in 30 experiment(s);

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Project description:Monodelphis domestica NODAL, nodal growth differentiation factor [Source:NCBI gene;Acc:100023464], is expressed in 2 baseline experiment(s);

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Project description:Rattus norvegicus Nodal, nodal growth differentiation factor [Source:RGD Symbol;Acc:1305994], is expressed in 1 baseline experiment(s);

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