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RNA-binding protein TRA2A promotes glioblastoma by mediating m6A RNA modification of IFITs to recycle p-EGFR

ABSTRACT: RNA-binding protein TRA2A promotes glioblastoma by mediating m6A RNA modification of IFITs to recycle p-EGFR

PROVIDER: PRJNA1060727 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27412064_1.fastq.gz	Fastqsanger.gz
	SRR27412064_2.fastq.gz	Fastqsanger.gz
	SRR27412065_1.fastq.gz	Fastqsanger.gz
	SRR27412065_2.fastq.gz	Fastqsanger.gz
	SRR27412066_1.fastq.gz	Fastqsanger.gz

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RNA-binding protein TRA2A promotes glioblastoma by mediating m6A RNA modification of IFITs to recycle p-EGFR

Project description:The RNA-binding protein Transformer 2 alpha homolog (TRA2A), previously identified as an alternative splicing factor, was reported as a crucial oncogene in recent years. However, the underlying mechanisms are poorly understood. In this study, we found that TRA2A is highly up-regulated in glioblastoma and is significantly correlated with clinical diagnosis and prognosis. We verified that TRA2A promotes the proliferation and metastasis of glioblastoma. Epitranscriptomic profiling further revealed Interferon-induced protein with tetratricopeptide repeat 1/2/3 (IFIT1/2//3) as the key RNA targets mediated by TRA2A, which further over-activates the EGFR-AKT signaling pathway by enhancing the recycling of p-EGFR. This work reveals a novel oncogenic mechanism of TRA2A in glioblastoma.

2024-01-19 | GSE252489 | GEO

The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

Project description:To address the functional implications at highthroughput level of TRA2A recruitment in FXTAS nuclear inclusions we performed Clariom D splicing arrays with the COS-7 cell models. We compared the profiles of the cells upon CGG overexpression, TRA2A overexpression and knockdown, with the respective controls.

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The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

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Incomplete paralog compensation generates selective dependency on TRA2A in cancer

Project description:Paralogs often exhibit functional redundancy, allowing them to effectively compensate for each other's loss. However, this buffering mechanism is frequently disrupted in cancer, exposing unique paralog-specific vulnerabilities. Here, we identify a selective dependency on the splicing factor TRA2A. We find that TRA2A and its paralog TRA2B are synthetic lethal partners that function as widespread and largely redundant activators of both alternative and constitutive splicing. While loss of TRA2A alone is typically neutral due to compensation by TRA2B, we discover that a subset of cancer cell lines are highly TRA2A-dependent. Upon TRA2A depletion, these cell lines exhibit a lack of paralog buffering specifically on shared splicing targets, leading to defects in mitosis and cell death. Notably, TRA2B overexpression rescues both the aberrant splicing and lethality associated with TRA2A loss, indicating that paralog compensation is dosage-sensitive. Together, these findings reveal a complex dosage-dependent relationship between paralogous splicing factors, and highlight how dysfunctional paralog buffering can create a selective dependency in cancer.

2025-04-17 | GSE294883 | GEO

CCDC50 promotes glioblastoma progression through regulating EGFR cell-surface recycle

Project description:CCDC50 promotes glioblastoma progression through regulating EGFR cell-surface recycle

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EGFR-AS1

Project description:Homo sapiens EGFR-AS1, EGFR antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40207], is expressed in 22 baseline experiment(s);

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EGFR-AS1

Project description:Homo sapiens EGFR-AS1, EGFR antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40207], is differentially expressed in 18 experiment(s);

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The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

Project description:The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

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The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

Project description:The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

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EGFR and MEK pathway signature RNA-Seq datasets

Project description:EGFR and MEK pathways were activated alone or in combination in human mammary epithelial cells. We profiled the pathway gene expression signatures using RNA-Seq. mRNA was extracted from human mammary epithelial cells overexpressing EGFR gene, MEK gene, or EGFR and MEK genes in combination (or GFP control) for RNA-Seq analysis. Experiment was performed in six replicates per condition.

2015-03-05 | E-GEOD-59765 | biostudies-arrayexpress

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