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RNA-Seq results of a neuronal cell model of SBMA, AR-97Q cells, compared to AR-24Q cells

ABSTRACT: RNA-Seq results of a neuronal cell model of SBMA, AR-97Q cells, compared to AR-24Q cells

PROVIDER: PRJNA1061129 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27421708.fastq.gz	Fastqsanger.gz
	SRR27421709.fastq.gz	Fastqsanger.gz
	SRR27421710.fastq.gz	Fastqsanger.gz
	SRR27421711.fastq.gz	Fastqsanger.gz
	SRR27421712.fastq.gz	Fastqsanger.gz

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RNA-Seq results of a neuronal cell model of SBMA, AR-97Q cells, compared to AR-24Q cells

Project description:Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by a polyglutamine expansion in the androgen receptor (AR). Transcriptional changes were compared between a muscle cell model of SBMA (AR-97Q cells) and a control model (AR-24Q cells). RNA-seq gene expression analysis revealed that differentially expressed genes were associated with upregulation of transforming growth factor β (TGFβ) signaling, mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF) signaling, calcium signaling, and NFκB signaling.

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Project description:To identify the gene expression changes that are specific to SBMA, we prepared total mRNA samples from the spinal cords of transgenic mice carrying a full-length human AR with 97 CAGs (AR-97Q), transgenic mice bearing a wild-type allele of AR with 24 CAGs (AR-24Q), and the wild-type littermates of the AR-97Q mice (C57BL/6). We used AR-97Q (Line #7-8) male mice because they show progressive muscular atrophy and weakness as well as SBMA-like pathology such as the accumulation of the pathogenic androgen receptor in the nucleus of motor neurons. Using microarray analysis, we identified the genes with significantly altered expression among the three types of mice. For each group, we examined the male mice at 7-9, 10-12, and 13-15 weeks of age. These stages were chosen because the AR-97Q mice are generally asymptomatic at 7-9 weeks of age (before-onset stage), present with mild motor impairment at 10-12 weeks (early stage), and are severely weakened with profound muscle atrophy at 13-15 weeks (advanced stage). RNA from the total spinal cord, excluding the dorsal root ganglia, was isolated from three mice of each genotype at each stage. For wild-type, pooled sample for three mice were used in each stage.

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