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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties

ABSTRACT: A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties

PROVIDER: PRJNA1061777 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27446723_1.fastq.gz	Fastqsanger.gz
	SRR27446723_2.fastq.gz	Fastqsanger.gz
	SRR27446724_1.fastq.gz	Fastqsanger.gz
	SRR27446724_2.fastq.gz	Fastqsanger.gz
	SRR27446725_1.fastq.gz	Fastqsanger.gz

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (HUVEC)

Project description:Tantalum (Ta) metal is well known for its ideal corrosion resistance and biological effects as endosseous implants. However, the metal has a elastic modulus as high as 186GPa which is not comparable to the natural bone (10-40GPa), and it also has a relative high cost. Here, to fully exploit the advantages of Ta as endosseous implants, a small amount of Ta (as low as 3 at.%) was successfully added into a zirconium-based metallic glass (MG) to generate an advanced functional endosseous implant, Zr58Cu25Al14Ta3 MG, with superior comprehensive properties. Upon carefully dissecting the surface chemistry and atomic structure, the results show that amorphization of Ta enable the uniform distribution in material surface, leading to a significantly improved chemical stability and extensive material-cell contact regulation. Systematical analyses on the immunological, angiogenesis and osteogenesis capability of the material is carried out by utilizing the next-generation sequencing, revealing that Zr58Cu25Al14Ta3 MG can regulate angiogenesis through VEFG signaling pathway and osteogenesis via BMP signaling pathway. Animal experiment further confirms a sound osseointegration of Zr58Cu25Al14Ta3 MG in achieving better bone-implant-contact and inducing faster peri-implant bone formation.

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (BMSC)

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties (xenograft)

Project description:A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties (xenograft)

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (BMSC)

Project description:A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (BMSC)

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (HUVEC)

Project description:A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties (HUVEC)

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevent properties

Project description:This SuperSeries is composed of the SubSeries listed below.

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A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties.

Project description: Not available

| S-EPMC11126771 | biostudies-literature

Lower Elastic Modulus of Novel Zr58Cu25Al14Nb3 Dental Implants Improves Stress Distribution and Osteogenesis in Peri-implant Alveolar Bone Under Physiological Loading

Project description:While implant materials with bone-mimetic elastic moduli are theoretically advantageous for reducing the stress shielding effect, the underlying mechanism remains incompletely understood, particularly in alveolar bone applications. In this study, we investigate the mechanism of excellent peri-implant bone quality of a Zr58Cu25Al14Nb3 bulk metallic glass (Nb3) dental implant in terms of its lower elastic modulus than commercial pure titanium (cpTi) and the stress distribution under masticatory mechanical loading. In vitro, Nb3 exhibits enhanced osteogenic potential over cpTi. In vivo, rat maxillary molar implants are subjected to a controllable cyclic loading program (10 N, 3 Hz, 0.12 s duration, 1800 cycles/day). The animal model coupled finite element analysis confirms that the lower elastic modulus of Nb3 implants promotes the more physiological stress distribution, and thus reduces stress concentration while increasing strain energy density in peri-implant bone. Histomorphometry reveals that loaded Nb3 implants significantly accelerate mineral apposition rate, upregulate collagen III, and increase osteoblast density while reducing osteocyte number, demonstrating improved mechano-adaptation. Transcriptomics identify coordinated upregulation of osteogenic, angiogenic, and mechanosensitive markers in Nb3-loaded bone. Immunohistochemistry validates elevated expression of osteopontin and periostin, key mediators of mechanical signaling. These findings establish that Nb3’s optimal elastic modulus enhances peri-implant bone quality through biomechanical optimization of stress transfer that further activates mechanotransductive osteogenesis, providing a material-based solution to stress shielding.

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4D printing of metallic metamaterials for bone implants via biodegradation

Project description:4D printing, integrating the temporal dimension into 3D printing, offers transformative potential for bone implants. Yet its application to metallic materials is constrained by the scarcity of suitable alloys and the requirement for harsh external stimuli to trigger shape change. Here, we introduce 4D printed metallic metamaterials (4DMM) driven by controlled biodegradation. The 4DMM combine biodegradable constraints (e.g., Mg or Zn) with biometals of higher corrosion potential (e.g., Ti). Upon electrochemical degradation of the constraint, the metamaterials recover their original geometry—via stretching, bending, or expansion—generating programmable recoil forces tuned through structural design parameters. When developed as scaffolds for bone implants, 4DMM exhibit excellent cytocompatibility and, in vivo, promote superior bone regeneration through the synergistic effects of bioactivity and mechanical stimulation. This strategy establishes a new paradigm in 4D metal printing via metamaterial design, enabling bioactive, self-restoring implants with broad applicability across biomedical engineering.

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