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Enhancing High-Quality Fat Survival: A Novel Strategy Using Cell Free Fat Extract

ABSTRACT: Enhancing High-Quality Fat Survival: A Novel Strategy Using Cell Free Fat Extract

PROVIDER: PRJNA1064097 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27505700_1.fastq.gz	Fastqsanger.gz
	SRR27505700_2.fastq.gz	Fastqsanger.gz
	SRR27505701_1.fastq.gz	Fastqsanger.gz
	SRR27505701_2.fastq.gz	Fastqsanger.gz
	SRR27505702_1.fastq.gz	Fastqsanger.gz

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Enhancing High-Quality Fat Survival: A Novel Strategy Using Cell Free Fat Extract

Project description:High-quality fat (HQF) contains a higher proportion of stromal vascular fraction, adipose-derived stem cells, and extracellular matrix components, surpassing the effectiveness of the traditional Coleman fat grafting method and improving volumetric filling. However, this high-quality fat strategy inevitably leads to a significant amount of unused fat being wasted. CEFFE, a cell-free extract derived from autologous fat tissue, is enriched with bioactive molecules. In this study, we further process the remaining fat from preparing HQF into CEFFE to promote the survival of transplanted fat. Our study introduces CEFFE, from the remaining fat from preparing HQF, as a promising adjunct to HQF grafting, showcasing notable enhancements in graft survival, adipose tissue integrity, and angiogenesis. The observed positive effects on ADSCs, including augmented stemness and adipogenic differentiation potential, further contribute to the overall improvement in fat graft outcomes. While these findings present a novel strategy for addressing the limitations of traditional fat grafting, additional research and clinical studies are imperative to validate the long-term efficacy, safety, and broader applicability of CEFFE in enhancing fat graft survival and promoting tissue regeneration.

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Cell-free fat extract promotes cornea epithelial repair and restores neurodegeneration via an anti-inflammation pathway

Project description:Corneal homeostasis is a complex process associated with various ocular pathologies, and the development of therapeutic strategies to promote neuroprotection and tissue regeneration is of great challenge. This study investigated the potential benefits of a cell-free fat extract in ameliorating neurodegenerative changes in laser-induced cornea neurodegeneration and alkali burn-induced epithelial injury mouse models. The cell-free fat extract, rich in bioactive compounds, was administered topically, and its effects on neuro regeneration and epithelial cell proliferation were evaluated. Our results exhibited a robust pro-proliferative effect on corneal epithelial cells, contributing to enhanced tissue regeneration in epithelial repair and significant improvement in neuroprotection, characterized by preserving corneal nerve density and branching complexity. These findings suggest that the application of cell-free fat extract holds promise as a novel therapeutic approach for addressing cornea neurodegeneration, offering neuroprotective effects, and promoting tissue repair. Further investigations into the underlying molecular mechanisms and long-term efficacy are warranted to advance the translational potential of this innovative intervention for ocular health.

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Effect of maple syrup extract on the liver of mice fed a high-fat diet

Project description:The effects of the administration of maple syrup extract (MSX) on hepatic gene expression were investigated in mice fed high-fat diet.

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Platycodi Radix Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model

Project description:This project investigated the molecular mechanism by which *Platycodi Radix* extract (PRE; the ethanol extract of the root of *Platycodon grandiflorum*) prevents non-alcoholic fatty liver disease (NAFLD) in a high-fat diet (HFD)-induced fatty liver mouse model, using a liver-tissue shotgun proteomic and bioinformatic approach. Five-week-old male C57BL/6J mice were acclimatized and then maintained for 12 weeks on one of three diets: a normal chow diet (NCD), a high-fat diet (HFD), or an HFD supplemented with 5% (w/w) PRE. PRE supplementation prevented HFD-induced body-weight gain, fat accumulation, and hepatic steatosis, and improved glucose tolerance and serum lipid profiles. To elucidate the underlying mechanism, liver proteomes of the NCD, HFD, and PRE groups were profiled by LC-MS/MS (n = 3 per group), and proteins differing in relative abundance between NCD vs HFD and HFD vs PRE were interpreted by Ingenuity Pathway Analysis. This LC-MS/MS dataset was designed as a discovery-stage, exploratory screen for hypothesis generation rather than as standalone quantitative proof of differential expression; the resulting candidate proteins and pathways (notably decreased FXR/RXR-activation proteins and increased cholesterol-biosynthesis proteins, predicting enhanced bile-acid synthesis) were subsequently validated by targeted Western blotting and biochemical bile-acid measurement, on which the mechanistic conclusions of the study are based. This dataset comprises the liver-tissue LC-MS/MS data and the protein identification/quantification results supporting the conclusion that PRE prevents hepatic steatosis through modulation of FXR/RXR activation, cholesterol biosynthesis, and bile-acid synthesis pathways.

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Effect of maple syrup extract high on the liver of mice fed a high-fat diet [III]

Project description:The effects of the administration of maple syrup extract (MSXH) on hepatic gene expression were investigated in mice fed high-fat diet.

2016-09-12 | GSE80628 | GEO

Effect of maple syrup extract high on the liver of mice fed a high-fat diet [II]

Project description:The effects of the administration of maple syrup extract (MSXH) on hepatic gene expression were investigated in mice fed high-fat diet.

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Project description:The effects of the administration of maple syrup extract (MSXH) on hepatic gene expression were investigated in mice fed high-fat diet.

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Effect of maple syrup extract on the liver of mice fed a high-fat diet

Project description:The effects of the administration of maple syrup extract (MSX) on hepatic gene expression were investigated in mice fed high-fat diet. Male C57BL/6J mice aged 3 weeks were purchased from Charles River Japan (Kanagawa, Japan) and housed in a room maintained at 23 ± 1°C and 49 ± 16% humidity with a 12-h light/dark cycle (light 08:00–20:00; dark 20:00–08:00). For 1 week acclimation period after purchase, all the mice were fed a low-fat diet (10 kcal% fat). Then, they were randomly divided into three different dietary groups: the first group with the food containing fat at 10 kcal% as low-fat diet, the second group with 45 kcal% as high-fat diet, and the third with HFD plus 0.06% MSX. The mice were fed ad libitum for 8 weeks.

2015-04-30 | E-GEOD-65667 | biostudies-arrayexpress

Cell-free fat extract promotes cornea epithelial repair and restores neurodegeneration via an anti-inflammation pathway

Project description:Cell-free fat extract promotes cornea epithelial repair and restores neurodegeneration via an anti-inflammation pathway

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