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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [Spatial Transcriptomics]

ABSTRACT: Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [Spatial Transcriptomics]

PROVIDER: PRJNA1064410 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27536825_1.fastq.gz	Fastqsanger.gz
	SRR27536825_2.fastq.gz	Fastqsanger.gz
	SRR27536826_1.fastq.gz	Fastqsanger.gz
	SRR27536826_2.fastq.gz	Fastqsanger.gz
	SRR27536827_1.fastq.gz	Fastqsanger.gz

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [Spatial Transcriptomics]

Project description:Objective: To spatially resolve the identified celltypes, subtypes and transcriptomic profiles from single-nuclei RNA-seq with matched 12 infrapatellar fat pad of knee OA patients using spatial transcriptomics sequencing.

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

Project description:Objective: To identify and characterize celltypes and distinct transcriptomic signatures present in the infrapatellar fat pad (IFP) of knee OA patients using single-nucleus RNA sequencing.

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

Project description:Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

Project description:Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

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Single-cell atlas of human infrapatellar fat pad and synovium unravels mechanisms of osteoarthritis-induced joint pathology

Project description:Infrapatellar fat pad (IPFP) and synovium, two joint tissues next to each other, play essential roles in regulating joint homeostasis and the progression of knee osteoarthritis (OA). However, the mechanisms regulating their function under healthy and diseased conditions are largely unknown. This study aims to analyze the cellular heterogeneity of these two tissues from normal and OA patients. Single cell and single nuclei transcriptomic profiling were performed on IPFP/synovium cells from four healthy donors and five OA patients. Subsequent bioinformatic analyses identified cell clusters, delineated differentiation routes of mesenchymal cells and macrophages, and identified novel cell-to-cell communication pathways in joint tissue.

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Proteomic Analysis of Infrapatellar Fat Pad in Osteoarthritis

Project description:The infrapatellar fat pad (IFP) is involved in the occurrence and progression of osteoarthritis (OA), yet the proteomic changes in the IFP during OA are not well understood. In this study, we selected the IFP from patients undergoing late-stage total knee arthroplasty as the experimental group, while the IFP from patients undergoing repair surgery for acute anterior cruciate ligament rupture served as the control group. Using label-free protein quantification technology, we analyzed the protein expression levels in the experimental and control groups. We identified 315 differentially expressed proteins that are primarily associated with functions such as coagulation, complement, fatty acid metabolism, and adipogenesis. These findings shed light on the potential molecular mechanisms underlying the involvement of the IFP in OA pathogenesis.

2024-01-24 | PXD048154 |

Synovium and Infrapatellar fat pad are one functional tissue unit sharing common mesenchymal progenitors and undergoing coordinated changes in osteoarthritis

Project description:The Infrapatellar fat pads (IFP) are two wedge shaped fatty structures situated below the kneecap (patella), lying either side of the patellar tendon, first described by Hoffa in 1904. Recent studies reveal that knee OA causes pathological fibrosis, stiffening, and inflammation of the synovium and IFP (4, 5) (6). Multiple groups, including our co-investigator Dr. Changhai Ding, reported that MRI signal intensity alteration in IFP is strongly associated with OA knee structural abnormalities and may serve as an imaging biomarker to predict OA progression in patients (7-10). However, we have limited knowledge regarding the regulation of synovium and IFP functions for joint homeostasis and OA development.

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Single-cell atlas of human infrapatellar fat pad and synovium unravels mechanisms of osteoarthritis-induced joint pathology

Project description:Single-cell atlas of human infrapatellar fat pad and synovium unravels mechanisms of osteoarthritis-induced joint pathology

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-07 | GSE253200 | GEO

Effusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis.

Project description:ObjectivesTo determine whether greater effusion-synovitis volume and infrapatellar fat pad (IFP) signal intensity alteration differentiate incident accelerated knee OA (KOA) from a gradual onset of KOA or no KOA.MethodsWe classified three sex-matched groups of participants in the Osteoarthritis Initiative who had a knee with no radiographic KOA at baseline (recruited 2004-06; Kellgren-Lawrence <2; n = 125/group): accelerated KOA: ⩾1 knee progressed to Kellgren-Lawrence grade ⩾3 within 48 months; common KOA: ⩾1 knee increased in radiographic scoring within 48 months; and no KOA: both knees had the same Kellgren-Lawrence grade at baseline and 48 months. The observation period included up to 2 years before and after when the group criteria were met. Two musculoskeletal radiologists reported presence of IFP signal intensity alteration and independent readers used a semi-automated method to segment effusion-synovitis volume. We used generalized linear mixed models with group and time as independent variables, as well as testing a group-by-time interaction.ResultsStarting at 2 years before disease onset, adults who developed accelerated KOA had greater effusion-synovitis volume than their peers (accelerated KOA: 11.94 ± 0.90 cm3, KOA: 8.29 ± 1.19 cm3, no KOA: 8.14 ± 0.90 cm3) and have greater odds of having IFP signal intensity alteration than those with no KOA (odds ratio = 2.07, 95% CI = 1.14-3.78). Starting at 1 year prior to disease onset, those with accelerated KOA have greater than twice the odds of having IFP signal intensity alteration than those with common KOA.ConclusionPeople with IFP signal intensity alteration and/or greater effusion-synovitis volume in the absence of radiographic KOA may be at high risk for accelerated KOA, which may be characterized by local inflammation.

| S-EPMC6381765 | biostudies-literature

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