Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [ChIP-seq]

ABSTRACT: HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [ChIP-seq]

PROVIDER: PRJNA1065294 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27560713_1.fastq.gz	Fastqsanger.gz
	SRR27560713_2.fastq.gz	Fastqsanger.gz
	SRR27560714_1.fastq.gz	Fastqsanger.gz
	SRR27560714_2.fastq.gz	Fastqsanger.gz
	SRR27560715_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [Polysome-Seq]

Project description:HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [Polysome-Seq]

| PRJNA1065293 | ENA

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ10472]

Project description:HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ10472]

| PRJNA1065295 | ENA

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [PRO-seq]

Project description:HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [PRO-seq]

| PRJNA1065292 | ENA

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ8080]

Project description:HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ8080]

| PRJNA1065296 | ENA

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ9511]

Project description:HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ9511]

| PRJNA1065427 | ENA

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ8080]

Project description:Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapies. The signature lesion in ccRCC is inactivation of the VHL tumor suppressor gene and consequent upregulation of the HIF transcription factor. An earlier case report described a ccRCC patient who was cured by an allogeneic stem cell transplant and later found to have donor-derived T cells that recognized a ccRCC-specific peptide encoded by a HIF-responsive endogenous retrovirus (ERVE-4). We report that ERVE-4 is one of many ERVs that are induced by HIF, translated into HLA-bound peptides in ccRCCs, and capable of generating antigen-specific T cell responses. Moreover, ERV expression can be induced in non-ccRCC tumors with clinical-grade HIF stabilizers. These findings have implications for leveraging ERVs for cancer immunotherapy.

2025-02-20 | GSE253327 | GEO

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ9511]

2025-02-20 | GSE253373 | GEO

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [RNA-Seq_QJ10472]

2025-02-20 | GSE253328 | GEO

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [ChIP-seq]

2025-02-20 | GSE253325 | GEO

HIF Regulates Multiple Translated Endogenous Retroviruses: Implications for Cancer Immunotherapy [PRO-seq]

2025-02-20 | GSE253324 | GEO