Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1066874 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR27663918_1.fastq.gz | Fastqsanger.gz | |||
| SRR27663918_2.fastq.gz | Fastqsanger.gz | |||
| SRR27663919_1.fastq.gz | Fastqsanger.gz | |||
| SRR27663919_2.fastq.gz | Fastqsanger.gz | |||
| SRR27663920_1.fastq.gz | Fastqsanger.gz |
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Project description:The intra-erythrocytic developmental cycle (IDC) of malaria parasites is synchronized with the time-of-day hosts feed, but the mechanism underpinning this coordination is unknown. Combining in vivo and in vitro approaches using rodent and human malaria parasites, we reveal that: (i) 57% of P. chabaudi genes exhibit 24 h “circadian” periodicity in expression; (ii) 58% of these genes lose rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of P. falciparum genes show circadian expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) is circadian and disrupting it in rodent models shortens the IDC by 2-3 hours; (v) diverse processes, including DNA replication, the ubiquitin and proteasome pathways, are affected by disruption of SR10 and loss of coordination with host rhythms. Our results reveal that malaria parasites are at least in part responsible for scheduling their IDC, explaining the fitness benefits of coordination with host rhythms.
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