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The role of the DRW1 mutation on the DNA 6mA abundance in rice grains. [6mA IP-seq]

ABSTRACT: The role of the DRW1 mutation on the DNA 6mA abundance in rice grains. [6mA IP-seq]

PROVIDER: PRJNA1067118 | ENA |

REPOSITORIES: ENA

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The role of the DRW1 mutation on the DNA 6mA abundance in rice grains. [6mA IP-seq]

Project description:DRW1 modulates the DNA 6mA levels at loci involved in hormone pathway, photosynthesis, carbon metabolism as well as cell division and proliferation .

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The targets of the DRW1 in rice grains. [DRW1-Flag cut tag]

Project description:The targets of the DRW1 in rice grains. [DRW1-Flag cut tag]

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The role of the DRW1 mutation on H3K27me3 levels in rice grains. [H3K27me3 cut tag]

Project description:DRW1 controls H3K27me3 abundance contributed to hormone pathway, photosynthesis, carbon metabolism as well as cell division and proliferation .

2025-05-29 | GSE253858 | GEO

The targets of the DRW1 in rice grains. [DRW1-Flag cut tag]

Project description:DRW1 binds genes contributed to hormone pathway, photosynthesis, carbon metabolism as well as cell division and proliferation .

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The role of the DRW1 mutation on chromatin accessibility in rice. [ATAC-Seq]

Project description:DRW1 controls chromatin accessibility around DNA 6mA- and H3K27me3-modified regions in rice.

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The role of the DRW1 overexpression on the gene expression levels and RNA m5C levels in rice grains.

Project description:DRW1 controls gene expression contributed to hormone pathway, photosynthesis, carbon metabolism as well as cell division and proliferation . DRW1 controls RNA m5C levels of transcripts contributed to hormone pathway, photosynthesis, carbon metabolism.

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The role of the DRW1 mutation on the gene expression levels in rice grains. [RNA-Seq]

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The role of the DRW1 mutation on H3K27me3 levels in rice grains. [H3K27me3 cut tag]

Project description:The role of the DRW1 mutation on H3K27me3 levels in rice grains. [H3K27me3 cut tag]

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Reduction N6AMT1-mediated 6mA DNA modification promotes tumor progression [MeDIP-seq]

Project description:Background: DNA N6-methyladenosine (6mA) as a novel epigenetic signaling modification in humans and has been implicated in progression and tumorigenesis of several cancers. However, the function and mechanisms of 6mA in breast cancer (BC), the most common cancer among women, are unclear. Methods: The clinical role of 6mA was investigated by immunohistochemical (IHC) staining and Kaplan-Meier analysis of BC and their normal tissues. 6mA immunoprecipitation (IP) sequencing, mRNA sequencing and bioinformatics analysis were used to screen and validate the direct targets of 6mA. Results: Decreases in N6AMT1 correlated with the extent of 6mA in BC tissues and predicted a worse overall survival of BC patients. Knockdown N6AMT1 markedly reduced 6mA in DNA and promoted the proliferation and migration of BC in vivo and in vitro, whereas overexpression of N6AMT1 had the opposite effect, indicating N6AMT1 is a functional methyltransferase for DNA 6mA and relates with gene transcription. Critical negative regulators of the cell cycle, such as RB1, P21, REST and TP53 were identified as targets of N6AMT1 in BC. Conclusion: These results suggest N6AMT1 enhances DNA 6mA levels to repress tumor progression via transcriptional regulation of cell cycle inhibitors.

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Reduction N6AMT1-mediated 6mA DNA modification promotes tumor progression [RNA-seq]

2022-03-31 | GSE166576 | GEO