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PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [WGBS]

ABSTRACT: PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [WGBS]

PROVIDER: PRJNA1068062 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27696460_1.fastq.gz	Fastqsanger.gz
	SRR27696460_2.fastq.gz	Fastqsanger.gz
	SRR27696461_1.fastq.gz	Fastqsanger.gz
	SRR27696461_2.fastq.gz	Fastqsanger.gz
	SRR27696462_1.fastq.gz	Fastqsanger.gz

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PRC2-AgeIndex: a universal biomarker of aging and rejuvenation

Project description:PRC2-AgeIndex: a universal biomarker of aging and rejuvenation

| PRJNA1068056 | ENA

PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [WGBS]

Project description:DNA methylation (DNAm) is one of the most reliable biomarkers of aging across many mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, age-dependent DNAm gain is less specified. Multiple studies have demonstrated that polycomb repressive complex 2 (PRC2) targets are enriched among the CpG sites which gain methylation with age. However, systematic whole-genome examination of all PRC2 targets in the context of aging methylome as well as determination of the pan-tissue or tissue-specific nature of these associations is lacking. Here, by analyzing DNAm data from different assays and from multiple young and old human and mouse tissues, we found that low-methylated regions (LMRs) which are highly bound by PRC2 in embryonic stem cells (PRC2 LMRs) gain methylation with age in all examined somatic mitotic cells. We also estimated that this epigenetic change represents around 90% of the age-dependent DNAm gain genome-wide. Therefore, we propose the “PRC2-AgeIndex,” defined as the average DNAm in PRC2 LMRs, as a universal biomarker of cellular aging in somatic cells. In addition, we demonstrate the application of this biomarker in the evaluation of different anti-aging interventions, including dietary restriction and partial epigenetic reprogramming.

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PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [ChIP-seq]

Project description:PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [ChIP-seq]

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PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [ChIP-seq]

2024-06-19 | GSE253773 | GEO

Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [WGBS]

Project description:Rejuvenation of tissues in physiologically aging mice can be accomplished by long-term partial reprogramming via expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc). To investigate the epigenetic determinants of partial reprogramming-mediated rejuvenation, we used whole genome bisulfite sequencing to carry out unbiased comprehensive profiling of DNA methylation changes in skin from mice subjected to partial reprogramming, as well as young and untreated old controls. We found a striking convergence of age- and rejuvenation-related epigenetic alterations on targets of the Polycomb repressive complex 2 (PRC2). These results are also supported by a likewise prominent enrichment of PRC2 targets in gene expression data, suggesting that PRC2 activity can modulate aging and mediate tissue rejuvenation.

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Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [WGBS]

Project description:Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [WGBS]

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PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.

Project description:DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm gain is less characterized. Studies have demonstrated that CpGs which gain methylation with age are enriched in Polycomb Repressive Complex 2 (PRC2) targets. However, whole-genome examination of all PRC2 targets as well as determination of the pan-tissue or tissue-specific nature of these associations is lacking. Here, we show that low-methylated regions (LMRs) which are highly bound by PRC2 in embryonic stem cells (PRC2 LMRs) gain methylation with age in all examined somatic mitotic cells. We estimated that this epigenetic change represents around 90% of the age-dependent DNAm gain genome-wide. Therefore, we propose the "PRC2-AgeIndex," defined as the average DNAm in PRC2 LMRs, as a universal biomarker of cellular aging in somatic cells which can distinguish the effect of different anti-aging interventions.

| S-EPMC11250797 | biostudies-literature

Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq]

2026-02-02 | GSE288574 | GEO

PRC2-AgeIndex: a universal biomarker of aging and rejuvenation

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-19 | GSE253987 | GEO

Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets

Project description:Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets

| PRJNA1225190 | ENA