Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: The Andes as a semi-permeable geographical barrier: genetic connectivity between structured populations in a colorful and widespread spider

PROVIDER: PRJNA1068173 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27701300.fastq.gz	Fastqsanger.gz
	SRR27701400.fastq.gz	Fastqsanger.gz
	SRR27701301.fastq.gz	Fastqsanger.gz
	SRR27701401.fastq.gz	Fastqsanger.gz
	SRR27701302.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 179

Similar Datasets

Single cell RNA sequencing profile of unique mesenchymal progenitor subsets from the murine brain

Project description:The sensitive central nervous system is protected from potentially toxic components in the circulation by a semi-permeable interface, the blood brain barrier (BBB). This barrier is tightly regulated by several stromal cell types, however in certain regions of the brain it requires distinct properties. In particular, two of these regions, the choroid plexus and the pituitary gland are considered differentially permeable compared to other regions. Perivascular mesenchymal progenitors are intimately associated with endothelium and are therefore key participants in the regulation of the BBB. Using a mesenchymal progenitor specific lineage tracing tool, gene expression in this population from the choroid plexus and pituitary gland was profiled at the single cell level to investigate the genetic programs that allow these regions to maintain their respective specific pervious properties.

2024-04-11 | GSE162733 | GEO

High-throughput single cell -omics using semi-permeable capsules

Project description:High-throughput single cell -omics using semi-permeable capsules

| PRJNA1232165 | ENA

Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) infection in retinal pigment epithelium

Project description:Zika Virus (ZIKV) induces ocular complications in infants born from ZIKV infected mothers during pregnancy. We previously reported that ZIKV is permeable to cells lining the blood-retinal barrier. In this study, we measure the alteration of host transcriptome by ZIKV using primary retinal pigmented epithelial (RPE) cells.

2022-03-18 | GSE169066 | GEO

Project description:Semi-permeable membrane-covered composting of sewage sludge with inoculation of microbial agent

| PRJNA999636 | ENA

Project description:Widespread Genetic Connectivity of Feral Pigeons Across the Northeastern Megacity

| PRJNA607495 | ENA

Caco-2 cocultured with THP-1, time course

Project description:Previously, we constructed a coculture model to analyze the effect of macrophages on intestinal epithelial cells, and found that TNF-a secreted from human macrophage-like THP-1 cells induced cell damage to intestinal epithelial Caco-2 cells (Exp.Cell.Res. 2006, 312(19):3909-19). In this study, we present activation of NF-kB in Caco-2 cells within 15 min after coculturing. To reveal how TNF-a secreted from THP-1 cells affects Caco-2 cells in an early stage of coculture, we exhaustively analyzed the changes of gene expression in Caco-2 cells cocultured with THP-1 cells over the time periods of 0, 1, 3, 6, 24, and 48 h by using a DNA microarray. Differentially expressed genes extracted with maSigPro demonstrated that IEX-1 was the lowest p-value gene, that is, the most significantly changed gene among the up-regulated genes. The genes expressed in a similar pattern to IEX-1 involved immunity, apoptosis, and protein kinase cascade. These findings suggest that the stimuli of TNF-a from THP-1 cells activates NF-kB, leading induction of various gene expression. This pattern of gene expression indicates that not only early defense response but also cell death occurs at the same time, causing inflammatory condition. Caco-2 cells were cultured for 14 days on a semi-permeable support, and THP-1 cells were differentiated with phorbol myristate acetate (PMA) for 4 days in 12-well plates. Then, the semi-permeable support membrane in which Caco-2 cells had been cultured was placed on the 12-well plates on which THP-1 has been cultured.

2010-04-06 | E-GEOD-17625 | biostudies-arrayexpress

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

| PRJNA975918 | ENA

Developmental profiling of gene expression in embryos of the spider Parasteatoda tepidariorum

Project description:The common house spider Parasteatoda tepidariorum is a chelicerate model organism for studying developmental mechanisms and their evolution in arthropods. In contrast to the well-studied model insect, Drosophila melanogaster, embryos of the spider undergo patterning in a cellular environment from early stages (at least after the number of the nuclei increase to 16). Use of spider embryos provide new opportunities to understand the evolution of developmental mechanisms underlying arthropod body plans. This analysis aims to generate genome-scale, developmental profiles of gene expression in embryos of the spider P. tepidariorum, which facilitate a wide range of studies using this spider species.

2018-04-05 | GSE112712 | GEO

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1

Project description:Nephrotic syndrome (NS) occurs when the glomerular filtration barrier becomes excessively permeable leading to massive proteinuria. In childhood NS, dysregulation of the immune system has been implicated and increasing evidence points to the central role of podocytes in the pathogenesis. Children with NS are typically treated with an empiric course of glucocorticoid (Gc) therapy; a class of steroids that are activating ligands for the glucocorticoid receptor (GR) transcription factor. Although Gc-therapy has been the cornerstone of NS management for decades, the mechanism of action, and target cell, remain poorly understood. We tested the hypothesis that Gc acts directly on the podocyte to produce clinically useful effects without involvement of the immune system. In human podocytes, we demonstrated that the basic GR-signalling mechanism is intact and that Gc induced an increase in podocyte barrier function. To gain mechanistic insight we performed RNA microarray and ChIP-sequencing and identified Gc regulation of motility genes.

2017-07-17 | E-MTAB-5235 | biostudies-arrayexpress

Captopril Restores Microglial Homeostasis and Reverses ASD-like Phenotype in a model of ASD induced by exposure in utero to anti-Caspr2 IgG.

Project description:We performed single-cell RNA sequencing (scRNA-seq) of hippocampal microglia to define transcriptional changes induced by prenatal exposure to maternal anti-Caspr2 antibodies and their modulation by treatment (Captopril). Male offspring were analyzed across four main groups: (1) Saline-treated Controls, (2)Captopril treated Controls, (3) Anti-Caspr2, saline-treated, and (4) Anti-Caspr2, Captopril-treated . scRNA-seq revealed a Captopril (blood–brain barrier-permeable ACE inhibitor)-responsive microglial subcluster in Anti-Caspr2 mice with dysregulated translation (eIF2 signaling) and metabolic pathways (mTOR, oxidative phosphorylation) relative to controls. Captopril reversed these pathway alterations and restored a homeostatic microglial transcriptional state. These data provide a single-cell transcriptomic resource linking prenatal anti-Caspr2 exposure to persistent microglial dysfunction and demonstrate pathway normalization with BBB-permeable ACE inhibition.

2025-09-22 | GSE308428 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data