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ABSTRACT: Intestinal flora of forest musk deer

PROVIDER: PRJNA1069064 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27725951_1.fastq.gz	Fastqsanger.gz
	SRR27725951_2.fastq.gz	Fastqsanger.gz
	SRR27725952_1.fastq.gz	Fastqsanger.gz
	SRR27725952_2.fastq.gz	Fastqsanger.gz
	SRR27725953_1.fastq.gz	Fastqsanger.gz

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Project description:Pneumonia can seriously threaten the life of forest musk deer (an endangered species). To gain a comprehensive understanding of pneumonia pathogenesis in forest musk deer, iTRAQ-based proteomics analysis was performed in diseased (Phe group) and normal (Ctrl group) lung tissues of forest musk deer that died of pneumonia. Results showed that 355 proteins were differentially expressed (fold change ≥ 1.2 and Q < 0.05) in Phe vs Ctrl experiments. GO/KEGG annotation and enrichment analyses showed that dysregulated proteins might play vital roles in bacterial infection and immunity. Given the close association of bacterial infection and pneumonia, 32 dysregulated proteins related to Staphylococcus aureus infection, bacterial invasion of epithelial cells, and pathogenic Escherichia coli infection were screened out. Among these 32 proteins, 13 proteins were mapped to the bovine genome. Given the close phylogenetic relationships of forest musk deer and bovine, the protein-protein interaction networks of the above-ment

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