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The effects of a low isoleucine diet on the liver expression of aged C57BL/6J.Nia mice of both sexes

ABSTRACT: The effects of a low isoleucine diet on the liver expression of aged C57BL/6J.Nia mice of both sexes

PROVIDER: PRJNA1071574 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27805500_1.fastq.gz	Fastqsanger.gz
	SRR27805500_2.fastq.gz	Fastqsanger.gz
	SRR27805501_1.fastq.gz	Fastqsanger.gz
	SRR27805501_2.fastq.gz	Fastqsanger.gz
	SRR27805502_1.fastq.gz	Fastqsanger.gz

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The effects of a low isoleucine diet on the liver expression of aged C57BL/6J.Nia mice of both sexes

Project description:Dietary isoleucine is a significant determinant of metabolic health and longevity. In this study, we found that even at an advanced age, both male and female mice received significant metabolic benefits from a low isoleucine diet. We collected liver tissues for transcriptomic analysis and the results found that the majority of age-driven changes is ameliorated with the administration of low isoleucine diet.

2024-09-17 | GSE254721 | GEO

Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice

Project description:The amino acid composition of the diet has recently emerged as a critical regulator of metabolic health. Consumption of the branched-chain amino acid isoleucine is positively correlated with body mass index in humans, and reducing dietary levels of isoleucine rapidly improves the metabolic health of diet-induced obese male C57BL/6J mice. However, it is unknown how sex, strain, and dietary isoleucine intake may interact to impact the response to a Western Diet (WD). Here, we find that although the magnitude of the effect varies by sex and strain, reducing dietary levels of isoleucine protects C57BL/6J and DBA/2J mice of both sexes from the deleterious metabolic effects of a WD, while increasing dietary levels of isoleucine impairs aspects of metabolic health. Despite broadly positive responses across all sexes and strains to reduced isoleucine, the molecular response of each sex and strain is highly distinctive. Using a multi-omics approach, we identify a core sex- and strain- independent molecular response to dietary isoleucine, and identify mega-clusters of differentially expressed hepatic genes, metabolites, and lipids associated with each phenotype. Intriguingly, the metabolic effects of reduced isoleucine in mice are not associated with FGF21 – and we find that in humans plasma FGF21 levels are likewise not associated with dietary levels of isoleucine. Finally, we find that foods contain a range of isoleucine levels, and that consumption of dietary isoleucine is lower in humans with healthy eating habits. Our results demonstrate that the dietary level of isoleucine is critical in the metabolic and molecular response to a WD, and suggest that lowering dietary levels of isoleucine may be an innovative and translatable strategy to protect from the negative metabolic consequences of a WD.

2025-06-25 | GSE271655 | GEO

Transcription profiling of mouse lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA)

Project description:A comparison of lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA) of mouse

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Transcription profiling of mouse lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA)

Project description:A comparison of lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA) of mouse

2005-01-01 | E-TIGR-97 | biostudies-arrayexpress

Liver Transcriptomics from Male and Female HET3 Mice on Control, Low Amino Acid and Low Isoleucine Diets when started in Young and Middle Aged Mice

Project description:Mice were put on either a control, low amino acid or low isoleucine diet at 9 weeks of age or 6 months of age and their liver transcriptomic expression was measured after 14 weeks and 18 months respectively on diet after an overnight fast. This was to discover the impact of sex, protein and isoleucine level on the metabolism of the liver.

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Liver Transcriptomics from Mice on a Control vs Low Isoleucine Diet

Project description:Mice were put on either a control or low isoleucine diet and their liver transcriptomic expression was measured in both the fasting and fed state. This was to discover the impact of reducing a single branched chain amino acid on the metabolism of the liver.

2021-04-21 | GSE168588 | GEO

Microglial heterogeneity in the ischemic stroke mouse brain of both sexes

Project description:Microglial heterogeneity in the ischemic stroke mouse brain of both sexes

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Hepatic lipid metabolism is altered in Ubiad1+/- mice of both sexes

Project description:Hepatic lipid metabolism is altered in Ubiad1+/- mice of both sexes

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Transcription profiling of mouse kidney and DBA strain among both sexes

Project description:An individual study of kidney tissue and DBA strain among both sexes

2005-01-01 | E-TIGR-94 | biostudies-arrayexpress

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

Project description:Untargeted lipidomics of liver samples from female and male DBA/2J or C57BL/6J mice fed a control diet, Western diet, or high- or low-isoleucine Western diet. Both positive and negative mode are included.

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