Project description:Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids. Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC50 values of 19.7 and 13.8 µM, respectively, compared to positive control dexamethasone with 11.7 µM. The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.
| S-EPMC10011249 | biostudies-literature
Project description:WGS of Stemona tuberosa
| PRJNA861697 | ENA
Project description:Transcriptome sequencing of Stemona tuberosa
| PRJNA985114 | ENA
Project description:row data of Stemona parviflora
| PRJNA850147 | ENA
Project description:Genome sequencing of Stemona tuberosa