Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional differences between intratumoral CD8+ T cells in young and aged tumors at single cell resolution

ABSTRACT: Transcriptional differences between intratumoral CD8+ T cells in young and aged tumors at single cell resolution

PROVIDER: PRJNA1074763 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27920507.fastq.gz	Fastqsanger.gz
	SRR27920508.fastq.gz	Fastqsanger.gz
	SRR27920509.fastq.gz	Fastqsanger.gz
	SRR27920510.fastq.gz	Fastqsanger.gz
	SRR27920511.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Transcriptional differences between intratumoral CD8+ T cells in young and aged tumors at single cell resolution

Project description:Single-cell RNA sequencing of intratumoral CD8+ T cells (and CD45+ cells) from young and aged mice

2024-03-14 | GSE255373 | GEO

Changes in chromatin accessibility in intratumoral CD8+ T cell subsets between young and aged TME

Project description:Here, we present genome-wide comparisons of chromatin accessibility from endogenous CD8+ T cells and transferred OT-1 CD8+ T cells in young vs. aged B16-OVA tumors using ATAC-seq. This ATAC-seq dataset includes three different intratumoral CD8+ T cell subsets, such as TProg: Slamf6+Tim-3-, TTerm: Slamf6-Tim-3+, and TTAD: Slamf6-Tim-3-, as well as naive CD8+ T cells from spleens.

2024-03-14 | GSE255230 | GEO

Young and aged mouse bladders

Project description:Young and aged mouse bladders

| PRJNA629290 | ENA

Single cell multiome profiles of bone marrow hematopoietic stem and progenitor cells from young and aged donors.

Project description:To investigate molecular differences between HSPCs from young and aged donors, we performed 10x Single Cell Multiome on bone marrow HSPCs from Young, Middle Aged, and Older Aged donors.

2024-06-24 | GSE235646 | GEO

Changes in chromatin accessibility in intratumoral CD8+ T cell subsets between young and aged TME

Project description:Changes in chromatin accessibility in intratumoral CD8+ T cell subsets between young and aged TME

| PRJNA1074054 | ENA

Hippocampal gene expression in aged and young HSD1 knockout mice

Project description:Mice deficient in the glucocorticoid-regenerating enzyme 11Î²-HSD1 resist age-related spatial memory impairment. To investigate the mechanisms/pathways involved, we used microarrays to identify differentially expressed hippocampal genes that associate with cognitive ageing and 11Î²-HSD1. Aged wild-type mice were separated into memory-impaired and unimpaired relative to young controls according to their performance in the Y-maze. All individual aged 11Î²-HSD1-deficient mice showed intact spatial memory. The majority of differentially expressed hippocampal genes were increased with ageing (e.g. immune/inflammatory response genes) with no genotype differences. However, the neuronal-specific transcription factor, Npas4 and immediate early gene, Arc were reduced (relative to young) in the hippocampus of memory-impaired but not unimpaired aged wild-type or aged 11Î²-HSD1-deficient mice. Quantitative RT-PCR and in situ hybridization confirmed reduced Npas4 and Arc mRNA expression in memory-impaired aged wild-type mice. These findings suggest that 11Î²-HSD1 may contribute to the decline in Npas4 and Arc mRNA levels associated with memory impairment during ageing, and that decreased activity of synaptic plasticity pathways involving Npas4 and Arc may, in part, underlie the memory deficits seen in cognitively-impaired aged wild-type mice. 20 samples, 5 groups of 4 biological replicates each. Young, Wild Type animals are overall controls

2015-11-23 | E-GEOD-68515 | biostudies-arrayexpress

Aged vs Young Camk2a+ Neuron Proteome

Project description:Comparison of aged and young Camk2a+ neuronal proteome by transduction of mice with AAV-Camk2a;PheRS+ followed by AzF administration for BONCAT labeling of neuronal proteomes.

2025-11-07 | PXD057488 | Pride

scRNAseq of spleen and atherosclerotic plaques from young and aged healthy and young and aged atherosclerotic mice

Project description:T cells change substantially with age and are involved in atherosclerosis. Aging is the strongest clinical risk factor for atherosclerosis so we profiled T cells in young and aged mice prior to atherosclerosis (healthy) and in young and aged atherosclerotic mice (diseased).

2023-08-22 | GSE210719 | GEO

Circadian mRNA expression in skeletal muscle of young and aged mice

Project description:Aging animals undergo a variety of changes in molecular processes. Among these, the cellular circadian clock has been shown to change as animals age. Moreover, there is evidence that also core circadian clock proteins could influence the ageing behavior of vertebrates. To investigate the interplay between aging and the circadian clock, we studied circadian mRNA expression in skeletal muscles from young (8 weeks) and aged (80 weeks) mice. In order to detect differences in circadian patterns, we used microarray-based transcriptome-wide time series of mRNA expression, containing 16 independent measurements for both young and aged animals. Each individual time point consists of total RNA from hind limb skeletal muscles from 3 different animals. Young and aged mice where entrained to 12 hr/12 hr light-dark conditions. From these mice, hind limb skeletal muscles were extracted at different times of day, in order to measure circadian mRNA expression patterns.

2016-03-31 | E-GEOD-75523 | biostudies-arrayexpress

Age-associated difference between young-adult and aged ferrets during SFTSV infection

Project description:This longitudinal scRNA-seq analysis examines age-related differences, focusing particularly on the B cell response, between young-adult and aged ferrets during SFTSV infection.

2025-08-01 | GSE287515 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data