Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Whole-genome sequence data for 88 outbred heterogeneous stock rats

PROVIDER: PRJNA1076141 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27957100_1.fastq.gz	Fastqsanger.gz
	SRR27957100_2.fastq.gz	Fastqsanger.gz
	SRR27957101_1.fastq.gz	Fastqsanger.gz
	SRR27957101_2.fastq.gz	Fastqsanger.gz
	SRR27957102_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 176

Similar Datasets

Project description:N/NIH heterogeneous stock (HS) outbred rats, low-coverage whole genome sequencing

| PRJNA1022514 | ENA

Transcriptomic regulation in the NAcc, PL, and pVTA brain regions in heterogeneous stock rats [posterior ventral tegmental area]

Project description:To aid in the investigation of behavioral trait genetic associations, we collected RNA-seq from three brain regions of 200 genotyped outbred heterogeneous stock (HS) rats. We mapped molecular QTLs and conducted transcriptome-wide association study (TWAS) involving a collection of 281 complex traits.

2026-03-26 | GSE325426 | GEO

Transcriptomic regulation in the NAcc, PL, and pVTA brain regions in heterogeneous stock rats [prelimbic cortex]

2026-03-26 | GSE325425 | GEO

Transcriptomic regulation in the NAcc, PL, and pVTA brain regions in heterogeneous stock rats [nucleus accumbens core]

2026-03-26 | GSE325482 | GEO

Project description:Gut microbiome genera associate with metabolic traits in outbred heterogeneous stock rats

| PRJNA1076230 | ENA

Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research [Lateral habenula]

Project description:Research into the genetic influences of impulsivity and reward motivated behavior relies heavily on outbred animal populations, including Heterogeneous Stock (HS) rats, for the genetic diversity necessary to identify genotype-trait associations. Many such associations have been detected, but it is not always clear which gene or other feature near the identified genomic location is functionally responsible for the association. Since these traits are in part mediated by gene expression, mapping the associations between genotype and gene expression in these animals will enable the discovery and deeper understanding of these trait associations. We therefore obtained genotypes and RNA-Seq gene expression for five brain regions from 88 HS rats and mapped expression quantitative trait loci (eQTLs) for each region. We identified cis-eQTLs in over 3,000 genes per brain region and validated their effect sizes using allele specific expression. This resource will enable new discoveries of the genetic influences of complex behavioral traits.

2021-04-23 | GSE173138 | GEO

Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research [Nucleus accumbens core]

2021-04-23 | GSE173136 | GEO

Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research [Prelimbic cortex]

2021-04-23 | GSE173139 | GEO

Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research [Orbitofrontal cortex]

2021-04-23 | GSE173140 | GEO

Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research [Infralimbic cortex]

2021-04-23 | GSE173137 | GEO