Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Developmental emergence of first- and higher-order thalamic neuron molecular identities

ABSTRACT: Developmental emergence of first- and higher-order thalamic neuron molecular identities

PROVIDER: PRJNA1076166 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27963100_1.fastq.gz	Fastqsanger.gz
	SRR27963100_2.fastq.gz	Fastqsanger.gz
	SRR27963200_1.fastq.gz	Fastqsanger.gz
	SRR27963200_2.fastq.gz	Fastqsanger.gz
	SRR27963300_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 4602

Similar Datasets

Developmental emergence of first- and higher-order thalamic neuron molecular identities

Project description:The thalamus is organized into nuclei that have distinct input and output connectivities with the cortex. While first-order (FO) nuclei – also called core nuclei – relay input from sensory organs on the body surface and project to primary sensory areas, higher-order (HO) nuclei – matrix nuclei – instead receive their driver input from the cortex and project to secondary and associative areas within cortico-thalamo-cortical loops. Input-dependent processes have been shown to play a critical role in the emergence of FO thalamic neuron identity from a ground state HO neuron identity, yet how this identity emerges during development remains unknown. Here, using single-nucleus RNA sequencing of the developing embryonic thalamus we show that FO thalamic identity emerges after HO identity, and that peripheral input is critical for the maturation of excitatory, but not inhibitory FO-type neurons. Our findings reveal that subsets of HO neurons are developmentally co-opted into FO-type neurons, providing a mechanistic framework for the diversification of thalamic neuron types during development and evolution.

2024-09-12 | GSE255688 | GEO

Developmental emergence of first- and higher-order thalamic neuron molecular identities.

Project description:The thalamus is organized into nuclei that have distinct input and output connectivities with the cortex. Whereas first-order (FO) nuclei - also called core nuclei - relay input from sensory organs on the body surface and project to primary cortical sensory areas, higher-order (HO) nuclei - matrix nuclei - instead receive their driver input from the cortex and project to secondary and associative areas within cortico-thalamo-cortical loops. Input-dependent processes have been shown to play a crucial role in the emergence of FO thalamic neuron identity from a ground-state HO neuron identity, yet how this identity emerges during development remains unknown. Here, using single-cell RNA sequencing of the developing mouse embryonic thalamus, we show that, although they are born together, HO neurons start differentiating earlier than FO neurons. Within the FO visual thalamus, postnatal peripheral input is crucial for the maturation of excitatory, but not inhibitory, neurons. Our findings reveal different differentiation tempos and input sensitivities of HO and FO neurons, and highlight neuron type-specific molecular differentiation programs in the developing thalamus.

| S-EPMC11463969 | biostudies-literature

Skin regional specification and higher-order HoxC regulation

Project description:Skin regional specification and higher-order HoxC regulation

| PRJNA1040303 | ENA

Higher-Order Organization Principles of Pre-translational mRNPs [RIPPLiT]

Project description:Higher-Order Organization Principles of Pre-translational mRNPs [RIPPLiT]

| PRJNA476057 | ENA

Regulation of somatic hypermutation by higher-order chromatin structure

Project description:Regulation of somatic hypermutation by higher-order chromatin structure

| PRJNA1141910 | ENA

Higher-order spatial organization of the Deinococcus radiodurans chromosomes

Project description:Higher-order spatial organization of the Deinococcus radiodurans chromosomes

| PRJNA1008341 | ENA

Regulation of somatic hypermutation by higher-order chromatin structure

Project description:Regulation of somatic hypermutation by higher-order chromatin structure

| PRJNA1132192 | ENA

DNA methylation maintains integrity of higher order genome architecture

Project description:DNA methylation maintains integrity of higher order genome architecture

| PRJNA663616 | ENA

Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations

Project description:Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations

| PRJNA1083585 | ENA

Gamma entrainment binds higher order brain regions and alleviates neurodegeneration

Project description:Gamma entrainment binds higher order brain regions and alleviates neurodegeneration

| PRJNA474231 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data