STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1076171 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR27962990_1.fastq.gz | Fastqsanger.gz | |||
| SRR27962990_2.fastq.gz | Fastqsanger.gz | |||
| SRR27962991_1.fastq.gz | Fastqsanger.gz | |||
| SRR27962991_2.fastq.gz | Fastqsanger.gz | |||
| SRR27962992_1.fastq.gz | Fastqsanger.gz |
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Project description:Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are yet to be fully characterized. Here, we identify STAT6 as a mitochondrial protein that is localized in the outer membrane of mitochondria (OMM). STAT6 in OMM inhibits mitochondrial fusion by blocking MFN2 dimerization. This implies that STAT6 has a critical role in mitochondrial dynamics. Moreover, mitochondrial accumulation of STAT6 in response to hypoxic conditions reveals that STAT6 is a regulator of mitochondrial processes including fusion/fission mechanisms.
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