Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Effects of Complement in a Chronic Murine Model of Inflammatory Erosive Arthritis and Pulmonary Vascular Disease

ABSTRACT: The Effects of Complement in a Chronic Murine Model of Inflammatory Erosive Arthritis and Pulmonary Vascular Disease

PROVIDER: PRJNA1076463 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27966804_1.fastq.gz	Fastqsanger.gz
	SRR27966804_2.fastq.gz	Fastqsanger.gz
	SRR27966805_1.fastq.gz	Fastqsanger.gz
	SRR27966805_2.fastq.gz	Fastqsanger.gz
	SRR27966806_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

The Effects of Complement in a Chronic Murine Model of Inflammatory Erosive Arthritis and Pulmonary Vascular Disease

Project description:Dysfunction of the complement pathway contributes to diseases such rheumatoid arthritis (RA) and pulmonary hypertension (PH). Here we aim to determine whether complement deficiency has a protective effect on joint and lung disease using the tumor necrosis factor-transgenic (TNF-Tg) mouse model with constitutive human TNF-ɑ expression characterized by spontaneous onset of inflammatory-erosive arthritis and PH.

2024-12-31 | GSE255755 | GEO

Single Cell Transcriptomic Analysis of Popliteal Lymph Nodes from TNF-Tg Mice with Early and Advanced Inflammatory-Erosive Arthritis

Project description:Immune cell dynamics in lymph nodes downstream of inflamed joints are associated with inflammatory-erosive arthritis in both tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. In TNF-Tg mice, "Early" stages of arthritis are related to dramatic PLN "Expansion" with increases in joint-draining popliteal lymph node (PLN) volume and fluid flow, while CD21-high / CD23+ B-cells in inflamed nodes (Bin cells) accumulate in the PLN follicles. Onset of "Advanced" inflammatory-erosive arthritis is related to a PLN "Collapse" where fluid flow is reduced as Bin cells translocate from the PLN follicles into the sinuses and are thought to mechanically inhibit lymphatic drainage. Through single-cell RNA-sequencing, we aimed to evaluate changes in PLN immune cell populations during Early and Advanced arthritis to determine mechanisms mediating the Bin cell translocation and the relationship with arthritic progession in the afferent joints.

2023-08-14 | GSE211124 | GEO

Osteoclast microRNA profiling to capture the erosive factor in rheumatoid arthritis

Project description:Background: In rheumatoid arthritis (RA), only a subset of patients develop an irreversible bone destruction. Our aim was to develop a microRNA (miR)-based osteoclast-related signature to predict erosiveness in RA. Results: We identified 5 miRs from PBMC-derived osteoclasts differentially expressed in RNASeq also in qPCR assessment. Conclusion: We found 5 miRNAs differentially refulated in erosive rheumtoid arhtritis compare to no erosve patient. This study could improve the current approach to identify RA subjects at risk of erosions, by adding biomarker signatures based on the profile of miRs in the osteoclasts.

2023-09-01 | GSE209982 | GEO

Osteoclast microRNA profiling to capture the erosive factor in rheumatoid arthritis

Project description:Osteoclast microRNA profiling to capture the erosive factor in rheumatoid arthritis

| PRJNA863270 | ENA

Spatial Transcriptomics of Joint-Draining Popliteal Lymph Nodes from Wild-type and TNF-Tg Mice with Early and Advanced Inflammatory-Erosive Arthritis

Project description:Lymphatic dysfunction is an integral aspect of rheumatoid arthritis (RA) pathogenesis. During "Early" arthritis in tumor necrosis factor transgenic (TNF-Tg) mice, the joint-draining popliteal lymph nodes (PLNs) dramatically expand in volume. After a prolonged expansion phase, at ~8-months-old the PLNs stochastically collapse with reduced bone volume and associated onset of "Advanced" inflammatory-erosive arthritis in affected joints. Through this pathologic process, B-cells are known to translocate into the PLN sinuses. Bulk tissue approaches (i.e. bulk genomics, flow cytometry, and ex vivo cell cultures) have been insufficient to specifically evaluate the transcriptional changes of B-cells within the sinuses of TNF-Tg PLNs. Thus, we utilized spatial transcriptomics technology to evaluate transcriptional changes in sinus B-cells and the functional genomic relationships with arthritic severity.

2023-08-14 | GSE195598 | GEO

Vascular remodeling following pulmonary hypertension

Project description:Hypoxia can induce vasoconstriction followed by vascular remodeling including hypertrophy and hyperplasia of pulmonary vascular smooth muscle and proliferation of endothelial cells. The goal of this project is to elucidate the genes involved in vascular remodeling following pulmonary hypertension. Total RNA was isolated from lungs of normoxic and hypoxic treated animals. Keywords: other

2003-07-16 | GSE482 | GEO

DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8

Project description:DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8

| PRJNA1068034 | ENA

Pulmonary Vascular Disease Phenomics Program (PVDOMICS)

Project description:Pulmonary Vascular Disease Phenomics Program (PVDOMICS)

| PRJNA740364 | ENA

Th2 cytokine IL-4 is critical in initiating pulmonary vascular inflammation under hypoxic conditions and induces pulmonary vascular endothelial cell activation.

Project description:IL-4-mediated pro-inflammatory vascular responses have been implicated in the pathogenesis of chronic cardiopulmonary diseases. Our results show that hypoxia-induced collagen synthesis and early recruitment of inflammatory cells are significantly less in the lungs of IL-4 knockout (KO) mice than in those of wild-type mice. In addition, we found that IL-4 significantly increased pro-inflammatory genes in primary pulmonary microvascular endothelial cells. This study was designed to identify the gene expression profile of IL-4-dependent pulmonary vascular inflammation induced by hypoxia.

2013-09-19 | E-GEOD-40999 | biostudies-arrayexpress

Transcription profiling of normoxic and hypoxic mice to elucidate the genes involved in vascular remodeling following pulmonary hypertension

2007-12-13 | E-GEOD-482 | biostudies-arrayexpress