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CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants

ABSTRACT: CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants

PROVIDER: PRJNA1076575 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27969150.fastq.gz	Fastqsanger.gz
	SRR27969151.fastq.gz	Fastqsanger.gz
	SRR27969152_1.fastq.gz	Fastqsanger.gz
	SRR27969152_2.fastq.gz	Fastqsanger.gz
	SRR27969153_1.fastq.gz	Fastqsanger.gz

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CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants

Project description:TTN CRISPR activation rescued TTNtv-related functional deficits despite increasing truncated TTN levels, which provides evidence to support haploinsufficiency as a relevant genetic mechanism underlying heterozygous TTNtvs (TTN truncation variants). CRISPR activation could be developed as a therapeutic to treat a large proportion of TTNtvs.

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