Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosha loss drives pineoblastoma by upregulating Ccnd2 [miR-eCLIP]

ABSTRACT: Drosha loss drives pineoblastoma by upregulating Ccnd2 [miR-eCLIP]

PROVIDER: PRJNA1077084 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27985088.fastq.gz	Fastqsanger.gz
	SRR27985089.fastq.gz	Fastqsanger.gz
	SRR27985090.fastq.gz	Fastqsanger.gz
	SRR27985091.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Drosha loss drives pineoblastoma by upregulating Ccnd2

Project description:Drosha loss drives pineoblastoma by upregulating Ccnd2

| PRJNA1076931 | ENA

Drosha loss drives pineoblastoma by upregulating Ccnd2 [miR-eCLIP]

Project description:Mutations in the microRNA processing genes DICER1 and DROSHA drive childhood cancers such as pineoblastoma, a brain tumor that resembles undifferentiated precursors of the pineal gland. To understand how microRNAs regulate proliferation of these progenitors, we developed a mouse model of pineoblastoma by ablating Drosha or Dicer1 in the developing pineal gland. The tumors that arise in these models resemble proliferative, undifferentiated embryonic progenitors. They are marked by loss of microRNAs, including the let-7 family, and de-repression of let-7 target genes. One upregulated let-7 target gene is the oncofetal transcription factor Plagl2, which activates expression of key pro-growth genes Igf2 and Ccnd2, and we show that small molecules targeting these two drivers block tumor growth. Thus, our results demonstrate that tumors driven by loss of microRNA processing may be therapeutically targeted by inhibiting downstream drivers of proliferation.

2024-10-03 | GSE255909 | GEO

Drosha loss drives pineoblastoma by upregulating Ccnd2 [ATAC-seq]

Project description:Drosha loss drives pineoblastoma by upregulating Ccnd2 [ATAC-seq]

| PRJNA1076930 | ENA

Drosha loss drives pineoblastoma by upregulating Ccnd2 [CUT&RUN]

Project description:Drosha loss drives pineoblastoma by upregulating Ccnd2 [CUT&RUN]

| PRJNA1076932 | ENA

Drosha loss drives pineoblastoma by upregulating Ccnd2 [smallRNAseq Drosha and Rb1 tumors]

Project description:Drosha loss drives pineoblastoma by upregulating Ccnd2 [smallRNAseq Drosha and Rb1 tumors]

| PRJNA1076943 | ENA

Drosha loss drives pineoblastoma by upregulating Ccnd2 [ATAC-seq]

2024-10-03 | GSE255905 | GEO