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ABSTRACT: Plasma exosomal miRNA sequencing

PROVIDER: PRJNA1078077 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28007179.fastq.gz	Fastqsanger.gz
	SRR28007180.fastq.gz	Fastqsanger.gz
	SRR28007181.fastq.gz	Fastqsanger.gz
	SRR28007182.fastq.gz	Fastqsanger.gz
	SRR28007183.fastq.gz	Fastqsanger.gz

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Diagnostic value of a panel of plasma exosomal miRNAs as potential biomarkers for thyroid nodules

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Project description:Purpose: Analysis of exosomal miRNA in plasma of patients with metastatic and non-metastatic pancreatic cancer. To identify exosomes cargo specific miRNAs promoting cancer metastasis. Methods: We divide the plasma samples into five groups according to whether they have metastasis and undergo surgery.The five groups are Health(20),Metastasis Pre-operation and Post-operation (14),Non-metastasis Pre-operation and Post-operation(9).Then we collected the exosomes by ultracentrifugation and extracted the small RNA in each sample.Then, we analyzed the expression changes of miRNA by small RNA sequencing. Result: Different groups have different expression of small RNA. Compared with the non-metastatic group, the expression of miR-92a-3p , miR-148-3p and miR-25-3p increased in the metastatic group. Conclusion:Exosomal miRNA in pancreatic cancer patient derived plasma were analyze using Hiseq2500 sequencing technique. We identified that miR-92a-3p, miR-148-3p and miR-25-3p enriched in metastatic pancreatic cancer patient plasma derived exosomes.

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