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Bojungikki-Tang Enhances the Efficacy of Pembrolizumab Treatment in Human PBMC-Injected H460 Tumor-Bearing Mice

ABSTRACT: Bojungikki-Tang Enhances the Efficacy of Pembrolizumab Treatment in Human PBMC-Injected H460 Tumor-Bearing Mice

PROVIDER: PRJNA1082260 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28164410.fastq.gz	Fastqsanger.gz
	SRR28164411.fastq.gz	Fastqsanger.gz
	SRR28164412.fastq.gz	Fastqsanger.gz
	SRR28164413.fastq.gz	Fastqsanger.gz
	SRR28164414.fastq.gz	Fastqsanger.gz

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Bojungikki-Tang Enhances the Efficacy of Pembrolizumab Treatment in Human PBMC-Injected H460 Tumor-Bearing Mice

Project description:Immune checkpoint inhibitors (ICIs) have become a major treatment option for non-small cell lung cancer, but their efficacy is still limited because only a subset of patients responded to ICIs. Bojungikki-Tang (BJIKT), a widely used herbal medicine extracted from 10 medicinal plants, has been largely investigated as a combined treatment with anticancer agents. In this study, we examined the potential anti-tumor effect of co-administration of BJIKT and pembrolizumab in human peripheral blood mononuclear cell (PBMC)-injected H460 tumor-bearing MHC Ⅰ/Ⅱ double knockout NSG mice. We found that combination treatment with BJIKT and pembrolizumab significantly suppressed tumor growth by regulating the activation of immune cells. Immunohistochemistry analysis showed that the combination therapy decreased the exhausted proportion of CD8(+) and CD4(+) T cells expressing PD-1 and LAG-3 markers in the tumor tissues. Our transcriptome analysis indicated that BJIKT strengthened T cell function and TNF signaling and inhibited TGF-β signaling to induce cell cycle arrest and apoptosis. Additionally, BJIKT synergistically exhibited anti-tumor effects along with immune-related pathways when combined with pembrolizumab. Taken together, combination therapy altered immune cells and regulated anti-tumor immune response, paving the way for a more effective understanding of the role of BJIKT in the tumor microenvironment.

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Project description:This study aimed to identify the modes of action (MOA) of water extract of Bojungikki-tang (BJIKT) and major four ingredients in immune cell lines. The four main ingredients were designated as Panax ginseng C. A. Meyer, Astragalus mongholicus Bunge, Atractylodes japonica Koidzumi, and Glycyrrhiza uralensis Fisher, which are the main active herbs of BJIKT. The immune-related cell lines used for transcriptome production are Jurkat (CD4+ T cells), RPMI8226 (B cells), NK-92MI (NK cells), M1MO (macrophages, differentiated from THP-1), and Mature DC (dendritic cells, differentiated from THP-1), respectively. This dataset contains transcriptome expression information for the RPMI8226 cell line.

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