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Single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

ABSTRACT: single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

PROVIDER: PRJNA1083512 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28215334_1.fastq.gz	Fastqsanger.gz
	SRR28215334_2.fastq.gz	Fastqsanger.gz

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single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

Project description:Despite known differences in immunologic features between anti-citrullinated peptide antibody (ACPA)-positive (ACPA+) and ACPA-negative (ACPA-) early rheumatoid arthritis (eRA) patients, our understanding is still incomplete. To address this, we performed single-cell RNA sequencing of CD45+ cells from peripheral blood samples of drug-naïve ACPA+ and ACPA- eRA patients and compared distribution and functional characteristics of cell subsets based on ACPA presence.

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Association of Epigenetic Trajectory With Development of Clinical Rheumatoid Arthritis in Individuals With Anti–Citrullinated Protein Antibody Positivity: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)

Project description:The presence of autoantibodies to citrullinated protein antigens (ACPAs) in the absence of clinically-apparent inflammatory arthritis (IA) identifies individuals “at-risk” for developing future clinical rheumatoid arthritis (RA). However, it is unclear why some ACPA+ individuals convert to clinical RA while others do not. We explored the possibility in the Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA) study that epigenetic remodeling is part of the trajectory from an at-risk state to clinical disease and identifies novel biomarkers associated with conversion to clinical RA.

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