Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic properties underlying transcriptional plasticity and evolvability in E. coli

ABSTRACT: Genetic properties underlying transcriptional plasticity and evolvability in E. coli

PROVIDER: PRJNA1083878 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genetic properties underlying transcriptional plasticity and evolvability in E. coli

Project description:The rate and direction of phenotypic evolution depends on the availability of phenotypic variants induced either genetically or environmentally for selection act upon. Theoretical suggest that genetic interactions between genes governing phenotypes could explain how the bias in phenotypic variability arises. However, it remains unknown whether the phenotypic variability is explained by real known genetic interactions as expected. To address this question, we analyzed transcriptional variability in a model microorganism, Escherichia coli, in response to different environmental and genetic perturbations. Thanks to the rich knowledge of the genetic interactions of E. coli, we identified common genetic properties that potentially affect transcriptional variability in both environmental and genetic causes. These empirical evidences support the relevance of the genetic interactions to shape phenotypic variability that is shared by different perturbations. Our results provide a mechanistic insight into how evolution learns from past environments to generalize to new environments.

2024-11-24 | GSE260863 | GEO

Molecular mechanisms underlying plasticity in a thermally varying environment

Project description:Molecular mechanisms underlying plasticity in a thermally varying environment

| PRJNA632473 | ENA

Chromatin rewiring mediates programmed evolvability via aneuploidy

Project description:Chromatin rewiring mediates programmed evolvability via aneuploidy

| PRJNA503195 | ENA

Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Project description:Systematic elucidation of genetic mechanisms underlying cholesterol uptake

| PRJNA955219 | ENA

Genetic Mutations and Cis-Regulatory Features Underlying Albinism

Project description:Genetic Mutations and Cis-Regulatory Features Underlying Albinism

| PRJNA1373322 | ENA

Genetic Mutations and Cis-Regulatory Features Underlying Albinism

Project description:Genetic Mutations and Cis-Regulatory Features Underlying Albinism

| PRJNA1373323 | ENA

Genetic variation underlying diapause induction

Project description:Genetic variation underlying local adaptation of diapause induction along a cline in a butterfly

| PRJEB28004 | ENA

Genetic and Behavioural Requirements for Structural Brain Plasticity

Project description:Genetic and Behavioural Requirements for Structural Brain Plasticity

| PRJNA514451 | ENA

Genetic and physiological mechanisms underlying flower induction in apple

Project description:Genetic and physiological mechanisms underlying flower induction in apple

| PRJEB40680 | ENA

Gene regulatory networks underlying intrinsic properties in human hematopoietic stem cell ontogeny

Project description:Human hematopoiesis starts at early yolk sac and undergoes site- and stage-specific changes over development. However, the gene regulatory networks (GRN) that drive the developmental changes in naive hematopoietic stem/progenitor cells (HSPCs) remain poorly understood. Here, we analyzed single-cell transcriptome of human naive HSPCs in different developmental stages, including yolk-sac (YS), AGM, fetal liver (FL), umbilical cord blood (UCB) and adult peripheral blood (PB) mobilized HSPCs. These stage-specific HSPCs display differential intrinsic properties, such as metabolism, self-renewal, differentiating potentialities etc. We generated highly co-related GRN modules underlying the differential HSC key properties. Particularly, we identified GRNs and key regulators controlling lymphoid potentiality, self-renewal and aerobic respiration in human HSCs. Introducing selected regulators promotes establishing key HSC functions in HSPCs derived from human pluripotent stem cells. Therefore, GRNs underlying key intrinsic properties of human HSCs provide a valuable guide to generate fully functional HSCs in vitro.

2024-03-19 | GSE224972 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data