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B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[CUT & RUN]

ABSTRACT: B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[CUT & RUN]

PROVIDER: PRJNA1083904 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28229791_1.fastq.gz	Fastqsanger.gz
	SRR28229791_2.fastq.gz	Fastqsanger.gz
	SRR28229792_1.fastq.gz	Fastqsanger.gz
	SRR28229792_2.fastq.gz	Fastqsanger.gz
	SRR28229793_1.fastq.gz	Fastqsanger.gz

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B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[Ribotag]

Project description:The establishment of long-lasting immunity against pathogens is facilitated by the germinal center (GC) reaction, during which B cells increase their antibody affinity, and differentiate into antibody-secreting cells (ASC) and memory cells. These events involve modifications in chromatin packaging that orchestrate the profound restructuring of gene expression networks that determine cell fate. While several chromatin remodelers were implicated in lymphocyte functions, less is known about SMARCA5. Here, by using ribosomal pull-down for analyzing translated genes in GC B cells, coupled with functional experiments in mice, we identified SMARACA5 as a key chromatin remodeler in B cells. While the naive B cell compartment and early B cell activation remained unaffected following conditional depletion of Smarca5, immunoglobulin class switching, GC formation and ASC differentiation were impaired. Single-cell multi-omic sequencing analyses revealed that SMARCA5 is crucial for facilitating the transcriptional modifications and genomic accessibility of genes that support B cell differentiation. These findings offer novel insights into SMARCA5, which can be targeted in lymphoma patients.

2024-09-01 | GSE270216 | GEO

B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[RNA-Seq]

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B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[CUT & RUN]

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B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[scMultiome - RNA + ATAC]

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B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling

Project description:B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling

| PRJNA1084819 | ENA

B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[Ribotag]

Project description:B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[Ribotag]

| PRJNA1125426 | ENA

B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[RNA-Seq]

Project description:B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[RNA-Seq]

| PRJNA1083906 | ENA

B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[scMultiome - RNA + ATAC]

Project description:B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling[scMultiome - RNA + ATAC]

| PRJNA1084825 | ENA

B cell differentiation into germinal center and antibody-secreting cells depends on SMARCA5-mediated chromatin remodeling

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-01 | GSE261015 | GEO

Proteome profiling of mouse germinal center B cells

Project description:Productive B cell responses are critical to protect a host from infection. The spleen and lymph nodes are populated by resting follicular B cells, which can enter germinal centers upon antigen encounter. Once in the germinal center, B cells migrate between the dark and light zones, where they undergo somatic hypermutation and selection, respectively. While germinal center B cells have been studied, an intense molecular understanding of these cells/subsets (and the differences between them) is lacking.

2020-04-06 | PXD015524 | Pride

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