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Gestational Exposure to Air Pollutants Perturbs Metabolic and Placenta-Fetal Phenotype

ABSTRACT: Gestational Exposure to Air Pollutants Perturbs Metabolic and Placenta-Fetal Phenotype

PROVIDER: PRJNA1085277 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28260902.fastq.gz	Fastqsanger.gz
	SRR28260903.fastq.gz	Fastqsanger.gz
	SRR28260904.fastq.gz	Fastqsanger.gz
	SRR28260905.fastq.gz	Fastqsanger.gz
	SRR28260906.fastq.gz	Fastqsanger.gz

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Gestational Exposure to Air Pollutants Perturbs Metabolic and Placenta-Fetal Phenotype

Project description:Introduction: Air pollution is detrimental to a pregnancy with adverse effects in mother and child. It is also known to increase pregnancy complications including risk factors of gestational diabetes. Methods: We investigated the impact of intra-nasal instilled air pollutants upon gestational day 16-19 maternal mouse cardiovascular and metabolic status, placental nutrient transporters, and placental-fetal size and morphology. To further unravel mechanisms, we also examined placental total DNA 5’-hydroxymethylation and bulk RNA sequenced gene expression profiles. Results: Air pollution exposed pregnant mice were tachycardic, hyperglycemic, glucose intolerant and insulin resistant, with no major placental glucose and fatty acid transporter changes, except for a spatial disruption of cells expressing GLUT10 that imports L-dehydroascorbic acid in protecting against oxidative stress. Placentas revealed inflammatory cellular infiltration with associated cellular edema and necrosis, with a paucity of vascularity and hemorrhage. While individual fetal body weights increased, they suffered a reduction in brain cortical thickness. Placental total DNA 5’-hydroxymethylation was 2.5-fold higher, with perturbed gene expression profiles involving key metabolic, inflammatory, transcriptional, cellular polarizing and processing genes and pathways. Discussion: We conclude that gestational exposure to air pollutants incites a maternal inflammatory response resulting in features of maternal gestational diabetes mellitus with altered placental gene expression with associated injury to the placental-fetal unit. Thus, air pollutants adversely impact the health of mother and offspring.

2025-03-07 | GSE261095 | GEO

Intestinal Microbiome in Response to Air Pollutant Exposure in Pregestational and Gestational Murine Females and their Offspring

Project description:This study aimed to examine the impact of intranasal exposure to air pollutants during eight weeks of preconception, periconception, and gestation (days 0 to 18) on the intestinal microbial composition, diversity, and metagenomically inferred functional pathways. The investigation focused on adult female mice during pregestational and late gestational periods (G19), as well as male and female postnatal suckling offspring (PN21), comparing the results with age- and sex-matched control groups (CON).

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Lewy body dementia promotion by air pollutants

Project description:Lewy body dementia promotion by air pollutants

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Reduced gene expression levels after chronic exposure to high concentrations of air pollutants

Project description:We analyzed the ability of particulate matter (PM) and chemicals adsorbed onto it to induce diverse gene expression profiles in subjects living in two regions of the Czech Republic differing in levels and sources of the air pollution. A total of 312 samples from polluted Ostrava region and 154 control samples from Prague were collected in winter 2009, summer 2009 and winter 2010. The highest concentrations of air pollutants were detected in winter 2010 when the subjects were exposed to: PM of aerodynamic diameter < 2.5 µm (PM2.5) (70 vs. 44.9 µg/m3); benzo[a]pyrene (9.02 vs. 2.56 ng/m3) and benzene (10.2 vs. 5.5 µg/m3) in Ostrava and Prague, respectively. Global gene expression analysis of total RNA extracted from leukocytes was performed using Illumina Expression BeadChips microarrays. The expression of selected genes was verified by quantitative real-time PCR (qRT-PCR). Gene expression profiles differed by locations and seasons. Despite lower concentrations of air pollutants a higher number of differentially expressed genes and affected KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways was found in subjects from Prague. In both locations immune response pathways were affected, in Prague also neurodegenerative diseases-related pathways. Over-representation of the latter pathways was associated with the exposure to PM2.5. The qRT-PCR analysis showed a significant decrease in expression of APEX, ATM, FAS, GSTM1, IL1B and RAD21 in subjects from Ostrava, in a comparison of winter 2010 and summer 2009. In Prague, an increase in gene expression was observed for GADD45A and PTGS2. In conclusion, high concentrations of pollutants in Ostrava were not associated with higher number of differentially expressed genes, affected KEGG pathways and expression levels of selected genes. This observation suggests that chronic exposure to air pollution may result in reduced gene expression response with possible negative health consequences.

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Effects of gestational exposure to air pollution on placental transcriptome

Project description:We report the expression pattern of placental transcriptome by Next Generation Sequencing from Gestational D19 mouse exposed to Air -Pollutant material with or without prior treatment with Fish Oil.

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Effects of gestational exposure to air pollution on placental methylation mark

Project description:We report the distribution of methylation mark by Next Generation Sequencing (RRBS) from Gestational D19 mouse exposed to Air -Pollutant material with or without prior treatment with Fish Oil.

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Effects of gestational exposure to air pollution on placental 5-Hydroxymethylation mark

Project description:We report the distribution of 5-Hydroxymethylation mark by Next Generation Sequencing from Gestational D19 mouse exposed to Air -Pollutant material with or without prior treatment with Fish Oil.

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Maternal gestational nutrition perturbs offspring sperm epigenome in sheep

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