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BAF60/SWP73 Subunits Define Subclasses of SWI/SNF Chromatin Remodelling Complexes in Arabidopsis

ABSTRACT: BAF60/SWP73 Subunits Define Subclasses of SWI/SNF Chromatin Remodelling Complexes in Arabidopsis

PROVIDER: PRJNA1085280 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28259130.fastq.gz	Fastqsanger.gz
	SRR28259131.fastq.gz	Fastqsanger.gz
	SRR28259132.fastq.gz	Fastqsanger.gz
	SRR28259133.fastq.gz	Fastqsanger.gz
	SRR28259134.fastq.gz	Fastqsanger.gz

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BAF60/SWP73 Subunits Define Subclasses of SWI/SNF Chromatin Remodelling Complexes in Arabidopsis

Project description:• Evolutionarily conserved SWI-SNF ATP-dependent chromatin remodeling complexes (CRCs) change nucleosome positioning and chromatin states, affecting gene expression to regulate important regulatory processes controlling such as proper development and hormonal signalling pathways. • In our study we used transcript profiling, chromatin immunoprecipitation (ChIP), exhaustive protein-protein interaction study including mass-spectrometry, yeast-two-hybrid and bimolecular fluorescence complementation (BiFC) along with hormone and metabolite profiling, and phenotype assessments to distinguish the functions of Arabidopsis SWP73A and SWP73B subunits in Arabidopsis. • We identified a novel subclass of SWI/SNF chromatin remodelling complexes defined by the presence of SWP73A subunit. Therefore, we propose a refined classification of SWI/SNF CRCs in Arabidopsis, introducing BAS-A (SWP73A-containing) and BAS-B (SWP73B-containing) subclasses. The SWP73A and SWP73B-carrying subclasses of SWI/SNF CRCs exhibit differential properties demonstrated by distinct chromatin binding patterns and divergent effect on hormone biosynthesis and metabolism. We found that SWP73A plays a specific role that cannot be fully compensated by SWP73B. We recognized that some atypical subclasses of SWI/SNF CRCs may be likely formed in mutant lines with inactivated SWP73 subunits. • Our study reveals that the duplication of the SWP73 subunit contributes to unique and shared functions of subclasses of SWI/SNF CRCs in the control of various regulatory processes in Arabidopsis.

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BAF60/SWP73 Subunits Define Subclasses of SWI/SNF Chromatin Remodelling Complexes in Arabidopsis

Project description:Evolutionary conserved SWI-SNF ATP-dependent chromatin remodeling complex changes nucleosome positioning and chromatin states, affecting gene expression to regulate developmental and hormonal pathways.  We showed the SWP73A and SWP73B - subunits of the SWI/SNF complex - differentially regulate gene expression related to metabolism and hormone biosynthesis, with opposite chromatin occupancy profiles.  The swp73b mutant exhibits hypersensitivity to auxin and salicylic acid (SA). SWP73B inactivation results in SA accumulation, but decreased gibberellin (GA) content and long-term GA treatment partially restored its phenotype.  Both SWP73 subunits are required for maintaining proper diurnal metabolite profiles, with SWP73A regulating essential genes of raffinose and glucosinolate metabolism.  Our study reveals that the duplication of the SWP73 subunit contributes to novel functions of the Arabidopsis SWI/SNF complex in gene transcription.

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Mitotic bookmarking by SWI/SNF subunits

Project description:Mitotic bookmarking by SWI/SNF subunits

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Mitotic bookmarking by SWI/SNF subunits

Project description:For cells to initiate and sustain a differentiated state, it is necessary that a “memory” of this state is transmitted through mitosis to the daughter cells. Mammalian SWItch/ Sucrose Non- Fermentable (SWI/SNF) complexes, also called Brg1/ Brg- associated factors (BAF), control cell identity by modulating chromatin architecture to regulate gene expression, but whether they participate in cell fate memory is unclear. Here, we provide evidence that subunits of SWI/SNF act as mitotic bookmarks to safeguard cell identity during cell division. The SWI/SNF core subunits SMARCE1 and SMARCB1 are displaced from enhancers but bound on promoters during mitosis and we show that this binding is required for appropriate reactivation of bound genes after mitotic exit. Ablation of SMARCE1 during a single mitosis in mouse embryonic stem cells is sufficient to disrupt gene expression, impair the occupancy of several established bookmarks at a subset of their targets, and cause aberrant neural differentiation. Thus, SWI/SNF subunit SMARCE1 plays a mitotic bookmarking role and is essential for heritable epigenetic fidelity during transcriptional reprogramming.

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