Project description:Humoral immunological memory is essential for the protection against pathogens post primary infection or vaccination. This protection relies on the long-term survival of pathogen-specific memory B cells and lone-lived plasma cells. We found that fasting impairs the humoral immunological memory by depleting the plasma cells. We performed functional analysis of these bone marrow plasma cells from Ad Lib mice or fasted mice.
Project description:Humoral immunological memory is essential for the protection against pathogens post primary infection or vaccination. This protection relies on the long-term survival of pathogen-specific memory B cells and lone-lived plasma cells. We found that ketogenic diet (KD) impairs the humoral immunological memory by depleting the plasma cells. We performed functional analysis of these bone marrow plasma cells from control mice or KD-treated mice.
