Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: pathogen that causes osteoarticular infections

PROVIDER: PRJNA1088114 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28347600.fastq.gz	Fastqsanger.gz
	SRR28347601.fastq.gz	Fastqsanger.gz
	SRR28347602.fastq.gz	Fastqsanger.gz
	SRR28347603.fastq.gz	Fastqsanger.gz
	SRR28347604.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 178

Similar Datasets

Acinetobacter

Project description:Multidrug resistance pathogen that causes nosocomial infections

| PRJNA836743 | ENA

Project description:Multidrug resistance pathogen that causes nosocomial infections

| PRJNA833266 | ENA

Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Project description:Opportunistic pathogen that causes multiple hospital-acquired infections

| PRJNA31 | ENA

Klebsiella pneumoniae

Project description:Opportunistic pathogen that causes multiple hospital-acquired infections

| PRJNA21073 | ENA

Proteome analysis of extracellular vesicles released from Streptococcus pyogenes

Project description:Streptococcus pyogenes (Group A Streptococcus: GAS) is a major human pathogen that causes streptococcal pharyngitis, skin and soft-tissue infections, and life-threatening conditions such as streptococcal toxic shock syndrome (STSS). A large number of virulence-related genes are encoded on GAS genomes, which are involved in host-pathogen interaction, colonization, immune invasion, and long-term survival within hosts, causing the diverse symptoms. Here, we investigated the interaction between GAS-derived extracellular vesicles and host cells in order to reveal pathogenicity mechanisms induced by GAS infection.

2021-05-17 | PXD026040 | JPOST Repository

Kingella kingae KK03 Type IV Pili

Project description:Type IV Pili (T4P) are dynamic surface appendages that mediate adherence, motility, and DNA uptake in Kingella kingae, an important pediatric pathogen that causes osteoarticular infections, bacteremia, and endocarditis. While the major pilin subunit in K. kingae T4P is well characterized, the contribution of minor pilins to T4P structure and function remains unknown. Here, we used proteomics, molecular genetics, biochemical analyses, and structural modeling to identify and characterize all eight minor pilins in K. kingae. We identified a conserved operon of core minor pilin genes encoding FimT, PilV, PilW, PilX, and PilE that promotes surface piliation, adherence to epithelial cells, twitching motility, and natural transformation. Deletion of the fimTpilVWXE locus phenocopied loss of the PilC1 and PilC2 adhesins, and AlphaFold modeling combined with bacterial two-hybrid analysis suggested that FimT, PilV, PilW, and PilX form a complex at the pilus tip. The PilA2, ComP, and KK03_01180 minor pilins were dispensable for adherence and motility but promoted natural transformation and formed protein-protein interactions with the major pilin, suggesting that these proteins are incorporated throughout the pilus shaft. These findings support a new model for the architecture of the K. kingae type IV pilus, with distinct minor pilins localizing to different sites on the pilus fiber and mediating specialized functions essential for virulence.

2025-10-06 | PXD068177 | Pride

Legionella hackeliae

Project description:Causes respiratory infections

| PRJNA35525 | ENA

Mycolicibacterium smegmatis

Project description:Causes opportunistic infections

| PRJNA35091 | ENA

Staphylococcus aureus

Project description:Causes skin infections

| PRJNA12304 | ENA

Enterococcus gallinarum

Project description:Causes opportunistic infections