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GEO accession GSE261719 is currently private and is scheduled to be released on Apr 01, 2026.

ABSTRACT: GEO accession GSE261719 is currently private and is scheduled to be released on Apr 01, 2026.

PROVIDER: PRJNA1088488 | ENA |

REPOSITORIES: ENA

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Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (ST)

Project description:Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (ST)

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Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (snRNA-Seq)

Project description:Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (snRNA-Seq)

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Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (ST)

Project description:We investigated how Hippo-deficient cardiac fibroblasts (CFs) alter their cell state and interact with immune cells during cardiac fibrosis. To study the role of the Hippo pathway in CFs, we conditionally knocked out Lats1/2 specifically in the CFs of mouse hearts (Lats1/2CKO). To test the role of Hippo-deficient CF-induced macrophages, we treated the control and Lats1/2CKO mice with or without CSF1R inhibitor to block macrophage expansion and performed ST.

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Hippo deficient cardiac fibroblasts differentiate into osteochondroprogenitors (snMultiomics)

Project description:We investigated how Hippo deficient CFs alter their cell state and interact with immune cells during cardiac fibrosis. To study the role of the Hippo pathway in CFs, we conditionally knocked out Lats1/2 specifically in the CFs of mouse hearts (Lats1/2-CF) and performed single-nucleus RNA sequencing (snRNA-seq) and single-nucleus multiomics to profile the cellular landscape of the right atria, with and without Csf1r inhibitor

2025-10-07 | GSE261719 | GEO

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Project description:We investigated how Hippo deficient CFs alter their cell state and interact with immune cells during cardiac fibrosis. To study the role of the Hippo pathway in CFs, we conditionally knocked out Lats1/2 specifically in the CFs of mouse hearts (Lats1/2-CF) and performed single-nucleus RNA sequencing (snRNA-seq) to profile the cellular landscape of the left and right atria.

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ETS2 and Mesp1 trans-differentiate human dermal fibroblasts into cardiac progenitors

Project description:We explored the role of mammalian ETS1/2 and Mesp homologues of cardiogenic transcription factors of Ciona intestinalis, to convert primary human dermal fibroblasts into cardiac progenitors. ETS1/2 and Mesp homologues of cardiogenic transcription factors of Ciona intestinalis, to convert primary human dermal fibroblasts into cardiac progenitors. Here we show murine Ets2 has an obligatory role for directing cardiac progenitors during cardiopoesis in embryonic stem cells. ETS2 converted fibroblasts into KDR/Flk1+ replicative cells but, like the purported cardiac master regulatory gene Mesp1, could not by itself generate cardiac progenitors de novo from fibroblasts. Co-expression of both Ets2 and Mesp1, however, successfully reprogrammed differentiated fibroblasts into cardiac progenitors, as shown by the de novo appearance of core cardiac transcription factors, gap junction proteins, sarcomeric proteins, electrical activity and contractility. ETS2 and Mesp1 sit at the pinnacle of the cardiopoesis regulatory hierarchy and are well suited for treating human heart disease. Co-expression of both Ets2 and Mesp1, reprogrammed differentiated fibroblasts into cardiac progenitors

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