Project description:This SuperSeries is composed of the following subset Series:; GSE10232: CTDG in PMA-activated Jurkat cells; GSE10233: CTDG in PMA-activated MM6 cells; GSE10234: CTDG in LPS-activated MM6 cells; GSE10737: CTDG in non-activated Jurkat cells; GSE10738: CTDG in non-activated MM6 cells; GSE10739: LPS and PMA response in parental MM6 cells Experiment Overall Design: Refer to individual Series
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression.
Project description:Asthma is a chronic inflammatory airway disease characterized by airway inflammation and remodeling. The role of 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-oxoETE), a 15-HETE metabolite catalyzed by 15-prostaglandin dehydrogenase (15-PGDH), has been relatively unexplored in asthma. In this study, we used RNA-seq to explore the effect of 15-KETE on the transcriptome of airway epithelial cells, aiming to identify its potential downstream targets and mechanisms of action.