Project description:Plants are constantly exposed to environmental changes and must respond carefully to ensure survival and growth. Under high temperatures, many plants exhibit a series of morphological and developmental adjustments, including increased hypocotyl and petiole elongation. These adaptations, collectively termed thermomorphogenesis, promote transpiration and water loss, thereby enhancing evaporative cooling. However, this phenomenon has primarily been described under well-watered conditions, whereas in nature, heat often coincides with other environmental challenges, such as drought. How thermomorphogenesis integrates with water shortage conditions, where excess water loss can be detrimental, remains unclear. Here, we demonstrate that restricting water availability and mimicking drought stress with mannitol inhibit thermomorphogenesis. Mechanistically, mannitol treatment reduces high temperature-induced transcriptional activation of PHYTOCHROME INTERACTING FACTOR4 (PIF4), a central regulator of thermomorphogenesis . This suppression is contributed by the enhanced production of plant phytohormone salicylic acid (SA), which disrupts phase separation and prevents the deactivation of EARLY FLOWERING 3 (ELF3), a repressor of PIF4, at high temperatures, thereby inhibiting PIF4 activation. Our study highlights the trade-off between cooling at high temperatures and minimizing excessive water loss under water-limited conditions, providing insights into plant responses to complex environmental challenges.
2025-07-04 | GSE287933 | GEO
Project description:Microorganisms present in central air-conditioning circulating cooling water pipe (Raw sequence reads)
Project description:Interventions: Before the start of treatment the patient receives clear oral and written instructions on the use of Cooral by the nurse responsible for the patient. The patient him/herself is able to administer the intraoral component until it feels comfortable. Then the responsible staff check to ensure that it has good contact with the oral mucous membrane. Cooling begins 30 minutes before the start of chemotherapy. Cooling continues until 30 minutes after the termination of the cytostatic infusion. During treatment the patient may if necessary take out the component and replace it again, for a maximum of 10 minutes. Food should thus be taken before or after chemotherapy.
Primary outcome(s): Feasibility for Cooral system during the first chemotherapy cycle.
Study Design: Single arm Non-randomized
Project description:Single-cell gene expression of circulating 41BBzeta CART19 cells isolated from lymphoma-bearing NSG mice treated with daily oral gavage of water or beta-hydroxybutyrate. Cells were captured and processed using 10X 3' GEX Reagent Kit v2