Project description:This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 mice and control mice. Experiment Overall Design: Refer to individual Series
Project description:To understand the effects of learning on expression in mouse striatum, we combined an automated operant conditioning chamber (OCC) setup with an efficient RNA-sequencing protocol. We compared 450 striatal expression profiles from 75 mice, e.g., the data contains 6 samples per mouse. Biopsies were taken from both hemispheres, three striatal regions (dorsoventral, dorsomedial, ventromedial striatum) at three learning stages (Early, Intermediate, Late). For each learning stage, there is the same number of samples from paired yoked control mice. There are also samples from control mice that were not kept in OCCs (Naive). The processed data can also be assessed and downloaded from here https://shiny.bio.lmu.de/Dopaloops/
