Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adenosine Kinase and ADAL Coordinate Detoxification of Modified Adenosines to Safeguard Metabolism

ABSTRACT: Adenosine Kinase and ADAL Coordinate Detoxification of Modified Adenosines to Safeguard Metabolism

PROVIDER: PRJNA1091898 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Adenosine Kinase and ADAL Coordinate Detoxification of Modified Adenosines to Safeguard Metabolism

Project description:RNA contains diverse post-transcriptional modifications, and its catabolic breakdown yields numerous modified nucleosides requiring correct processing, but the mechanisms remain unknown. Here, we demonstrate that three RNA-derived modified adenosines, N6-methyladenosine (m6A), N6,N6-dimethyladenosine (m6,6A), and N6-isopentenyladenosine (i6A), are sequentially metabolized into inosine monophosphate (IMP) to mitigate their intrinsic cytotoxicity. After phosphorylation by adenosine kinase (ADK) they undergo deamination by adenosine deaminase-like (ADAL). In Adal knockout mice, N6-modified adenosine monophosphates (AMPs) accumulate and allosterically inhibit AMP-activated protein kinase (AMPK), dysregulating glucose metabolism. Furthermore, ADK deficiency, linked to human inherited disorders of purine metabolism, elevates levels of the three modified adenosines, resulting in early lethality in mice. Mechanistically, excessive m6A, m6,6A, and i6A impairs lysosomal function by interfering with lysosomal membrane proteins, thereby disrupting lipid metabolism and causing cellular toxicity. Through this nucleotide metabolism pathway and mechanism, cells detoxify modified adenosines, linking modified RNA metabolism to human disease.

2025-08-20 | GSE262450 | GEO

m6A is decoded by modified tRNAs to coordinate mRNA decay.

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay.

| PRJNA1043151 | ENA

m6A is decoded by modified tRNAs to coordinate mRNA decay [miCLIP]

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay [miCLIP]

| PRJNA1041786 | ENA

m6A is decoded by modified tRNAs to coordinate mRNA decay [RNA-Seq]

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay [RNA-Seq]

| PRJNA1044139 | ENA

m6A is decoded by modified tRNAs to coordinate mRNA decay [ribosome profiling]

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay [ribosome profiling]

| PRJNA727761 | ENA

m6A is decoded by modified tRNAs to coordinate mRNA decay [SLAM-Seq]

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay [SLAM-Seq]

| PRJNA1040127 | ENA

m6A is decoded by modified tRNAs to coordinate mRNA decay [Quant-seq]

Project description:m6A is decoded by modified tRNAs to coordinate mRNA decay [Quant-seq]

| PRJNA1235615 | ENA

Manganese detoxification by Staphylococcus aureus

Project description:Manganese detoxification by Staphylococcus aureus

| PRJNA511462 | ENA

MIT/CMIT detoxification

Project description:Determination of the genetic basis for MIT/CMIT detoxification

| PRJEB89844 | ENA

Adenosine induced gene expression

Project description:Adenosine induced gene expression

| PRJNA891699 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data