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Overexpression of miR-200c/141 and miR-200b/200a/429 in MDA-MB-436 cells

ABSTRACT: Overexpression of miR-200c/141 and miR-200b/200a/429 in MDA-MB-436 cells

PROVIDER: PRJNA1091958 | ENA |

REPOSITORIES: ENA

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Overexpression of miR-200c/141 and miR-200b/200a/429 in MDA-MB-436 cells

Project description:We previously showed that overexpression of the miR-200c/141 cluster in the TNBC cell line MDA-MB-231 significantly reduced proliferation and invasion in vitro and tumor growth and metastasis in vivo. To confirm the effects of miR-200s in another TNBC cell line, MDA-MB-436 cells were created to overexpress both the miR-200c/141 cluster and the miR-200b/200a/429 cluster.

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Transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor development in MTB-TAN mice

Project description:We have previously shown that transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor development in MTB-IGFIR mice. In this study we evaluated whether the miR-200b/200a/429 cluster could also prevent mammary tumor development from a different oncogene, namely Neu/Erbb2. We found that transgenic overexpression of Neu/Erbb2 in MTB-TAN mice induce rapid mammary tumor development and co-overexpression of the miR-200b/200a/429 cluster with Neu/Erbb2 completely prevent mammary epithelial transformation and tumor development

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The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in murine claudin-low mammary tumor cells

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Transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor development in MTB-TAN mice

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miR-200b/200a/429 cluster prevents metastasis and induces dormancy in murine claudin-low mammary tumor cells

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Searching for target genes of miR-429 in HCCLM3 cells

Project description:miRNAs are an class of small noncoding RNAs and about 21-25 nucleotides in length. miRNAs inhibit the translation or induce mRNA degradation by binding to the 3’ UTR of target mRNAs and have been identified as the tumor promoters or suppressors regulating the progression of cancers. miR-429, which is a member of an evolutionarily conserved family of miRNAs that includes miR-200b, miR-200a, miR-200c and miR-141, is expressed in various epithelial tissues. Our goal is to search the possible target genes of miR-429 in human liver cancer cell line HCCLM3. We analyzed possible target genes of miR-429 by identifying the shared genes among the down-regulated genes in epithelial cell adhesion molecule (EpCAM) negative HCCLM3 cells which treated with miR-429 mimics and the up-regulated genes in EpCAM positive HCCLM3 cells which treated with Antagomir-429.

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Transgenic overexpression of the miR-200b/200a/429 cluster inhibits mammary tumor initiation.

Project description: Not available

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MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma

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