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The function of USP36 in the ER positive Breast Cancer

ABSTRACT: The function of USP36 in the ER positive Breast Cancer

PROVIDER: PRJNA1092965 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28484188.fastq.gz	Fastqsanger.gz
	SRR28484189.fastq.gz	Fastqsanger.gz
	SRR28484190.fastq.gz	Fastqsanger.gz
	SRR28484191.fastq.gz	Fastqsanger.gz
	SRR28484192.fastq.gz	Fastqsanger.gz

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The function of USP36 in the ER positive Breast Cancer

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2025-06-17 | GSE286447 | GEO

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Project description:The immune system's role in estrogen receptor (ER)-positive breast cancer is poorly understood. A population-based cohort of 428 breast cancer patients with clinical and molecular data was analyzed to assess how immune biomarkers can inform treatment decisions. Tumor-intrinsic immune responsiveness and local immune infiltration were quantified, and epithelial cell states were derived using EcoTyper. The interaction between ProliferativeIndex and Immunescore predicted risk of local recurrence in ER-positive tumors (HR 0.56, 95% CI 0.36-0.88, p=0.012). EcoTyper identified two epithelial cell states, S04 and S05, with distinct immunomodulatory properties. S04 tumors showed higher proliferation, enrichment for M1 macrophages, CD8 effector T-cells, and plasma cells, alongside hypomethylation of immune-related pathways and hypermethylation of the PI3K signaling pathway. In contrast, S05-enriched tumors were associated with fibroblast activation, immune exclusion, and enrichment for glycosylation-related pathways. These findings suggest that epithelial cell states shape immune responsiveness in ER-positive breast cancer and may inform biomarker-driven treatment strategies.

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